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NCT Number: NCT07084727

Identifying Biomarkers for Endothelial Dysfunction in Women With Preeclampsia

Every pregnancy has a major impact on a woman's heart and blood vessels due to changes required by the body to maintain proper blood flow between mother and foetus. When the placenta does not work properly, preeclampsia can occur. An important first symptom is high blood pressure. Women who have experienced preeclampsia are at higher risk of developing blood pressure and heart problems later on. Therefore, it is very important to detect changes in the blood vessel system so that they can be treated promptly and correctly. We aim to do this by using a new, non-invasive eye test that examines the blood vessels of the retina.

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Key information

Conditions

Endothelial Function (FMD) Female Urogenital Diseases and Pregnancy Complications Hypertension, Pregnancy-Induced Pre-Eclampsia Preeclampsia Pregnancy Complications Retinal Vessels Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Antwerp University Hospital

Edegem, Antwerp, 2650, Belgium

Location status: Recruiting

Location contact

Studies cardiologie

CONTACT

[email protected]

+32 3 821 40 74

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • at least 18 years old
  • willing to undergo vascular assessments
  • informed consent signed

Exclusion criteria

  • Unwilling to provide informed consent
  • Open-angle glaucoma
  • Epilepsia
  • (gestational) Diabetes
  • Multiple pregnancies
  • Fetal malformations
  • Hypercholesterolemia
  • Kidney disease
  • Auto-immune disorders
  • Connective tissue diseases

Treatment and study plan

Arterial Stiffness

Other

Non-invasive test. A blood pressure cuff and tonometer (a type of pen placed on the neck) are used to measure the speed at which a pressure wave propagates from one place to another.

Every time the heart contracts, a pressure wave is generated that propagates from the heart to the blood vessels at a certain speed. The stiffer the blood vessels, the faster the wave propagates.

Flow-meditad dilatation

Other

This study measures the capacity with which blood vessels expand when we briefly cut off blood flow. The endothelium, the inner layer of blood vessels, regulates this expansion. By ultrasound, we measure the difference in diameter of the elbow artery. To cut off the blood flow, we clamp the forearm with a blood pressure cuff for 5 minutes.

When the blood pressure cuff is released, it triggers increased blood flow in the arm, causing the blood vessels to expand. We record this expansion using the above techniques.

Dynamic retinal vessel analyzer

Other

Eye imaging measures the capacity with which your blood vessels in the retina can expand in response to a flicker light stimulation.

Primary outcomes

  1. Retinal biomarkers

    Time frame: Baseline

    Early (retinal) biomarkers for cardiovascular risk in patients with preeclampsia, assessed by DVA.

Study contacts

Contact information is provided by the study sponsor or research team.

Studies cardiologie

CONTACT

[email protected]

+32 3 821 40 74

Sponsors and collaborators

Lead sponsor

University Hospital, Antwerp

Other

Registry information

Official study title

Retinal Biomarkers as a Tool for Early Detection of Endothelial Dysfunction in Women With Preeclampsia

Acronym: DAISY

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 24, 2025
Registry last updated
Jul 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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