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Completed

NCT Number: NCT02405468

Identification of the Blood Microbiota in Patient Suffering From Myocardial Infraction

The investigators want to compare blood microbiota profile between patients with documented coronary lesions and patients free of coronary disease.

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Key information

Conditions

Coronary Disease Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

35 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

UHToulouse

Toulouse, 31000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cases : patients who have had a myocardial infarction within one month to one year before the inclusion
  • Controls : patients without history of myocardial infarction, free of coronary disease in the view of one of the following tests performed within one year before the inclusion :

Effort test Echocardiographic stress test Myocardial perfusion scintigraphy Coronarography with >= 2 major cardiovascular risk factors:

  • Treated hypertension,
  • Treated dyslipidemia
  • Current smoking
  • Diabetes mellitus

Exclusion criteria

  • Infectious disease within one week before the inclusion
  • Immunocompromised patients
  • Antibiotic treatment within one month before the inclusion
  • Chronic viral infection
  • Chronic inflammatory intestinal bowel disease
  • Renal failure (estimated glomerular filtration rate< 50 ml/min//1.73 m2)
  • Pregnancy

Treatment and study plan

Primary outcomes

  1. blood bacterial 16s rDNA bacterial gene concentration

    Time frame: 12 months

    compare blood bacterial 16s rDNA bacterial gene concentration

Secondary outcomes

  1. blood microbiota profile

    Time frame: 12 months

    compare blood microbiota profile as assessed at all taxonomic levels of interest (genus, family, order, class, phylum)

Other outcomes

  1. lipid profile

    Time frame: 12 months

    Obtain an accurate lipid profile with a new technic of microelectrophoresis(Lipoprint)

  2. functional HDL

    Time frame: 12 months

    Analyse the functional qualities of the HDL from the serum

  3. microARN profile

    Time frame: 12 months

    Search a microARN profile corresponding to the coronary heart disease

  4. Serum Bank and DNA Bank

    Time frame: 10 years

    Form a Serum Bank and a DNA Bank for potential future analysis guided by microARN research

  5. modifications of the blood microbiota

    Time frame: 12 months

    Analyse modification of the blood microbiota in the case and the control

Sponsors and collaborators

Lead sponsor

University Hospital, Toulouse

Other

Registry information

Acronym: FLORINF

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Apr 1, 2015
Registry last updated
Feb 17, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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