CHU de Dijon
Dijon, 21079, France
Completed
NCT Number: NCT01907477
Identification of Serum and/or Plasma Biomarkers for the Diagnosis Prognosis and/or Prediction of Invasive Mycosis in Neutropenic Patients
The aim of the present work is to study the protein expressions profiles of neutropenic patients (with a high risk of invasive mycosis) who developed - versus who did not develop invasive mycosis (principally aspergillosis and candidosis) in order to identify biomarkers for the diagnosis, prognosis and /or prediction of invasive mycosis.
Completed
Looking for future studies?
Notify MeKey information
Conditions
Age range
14 year and older
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- - Patients with malignant haemopathy who received chemotherapy likely to lead to severe neutropenia (PN<500/mm3) for a foreseeable period of 10 days.
- Patients aged 14 years or older (no upper age limit)
- Patients with malignant haemopathy who received an autologous marrow graft.
- Patients with severe idiopathic medullar aplasia (PN<500/mm3) who need to be hospitalised for at least 10 days consecutively (with or without immunosuppressant treatment).
- Patients who have provided written informed consent to participate in this study.
Exclusion criteria
- Patients who received an allograft of marrow or hematopoietic stem cell transplant (given that these patients carry a risk of aspergillosis, which in most cases appears after medullar recovery, they will not be included in the study).
- Patients who received an autologous hematopoietic stem cell transplant (given that the duration of the neutropenia is often less than 10 days).
- Patients who do not meet the inclusion criteria
- Persons not covered by the national Health Insurance Agency
Treatment and study plan
Samples taken at the clinical hematology unit
OtherPrimary outcomes
-
the variability of protein profiles
Time frame: baseline
Sponsors and collaborators
Lead sponsor
Centre Hospitalier Universitaire Dijon
Other
Registry information
Important dates
- Study start
- 2008
- Primary completion
- 2012
- Study completion
- 2012
- First posted
- Jul 25, 2013
- Registry last updated
- Jul 24, 2019
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.