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OpenTrials
Completed

NCT Number: NCT00773565

Identification of Novel Targets for Regulation of Adipose Tissue Mass

The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Heidelberg

Heidelberg, 69115, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants of the OPTIFAST52 program
  • BMI > 30 kg/m2

Exclusion criteria

  • Rejection of informed consent by the participant

Treatment and study plan

Optifast

Dietary Supplement

Formula diet for twelve weeks combined with physical activity and behavioral therapy

Primary outcomes

  1. number of adipocytes and preadipocytes under weight loss

    Time frame: three years

Secondary outcomes

  1. metabolic function of adipocytes and preadipocytes under weight loss

    Time frame: three years

Sponsors and collaborators

Lead sponsor

Gottfried Rudofsky

Other

Collaborators

  • Swiss Federal Institute of Technology

Registry information

Important dates

Study start
2008
Primary completion
2011
Study completion
2011
First posted
Oct 16, 2008
Registry last updated
Aug 23, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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