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NCT Number: NCT06569134

Identification of Neuroprognostic Factors for Out-of-hospital Cardiopulmonary Arrest (MIRA29)

From the informatized prehospital care registry, data will be collected anonymously for all patients' requiring cardiopulmonary resuscitation for an out-of-hospital cardiac arrest within the Norther Finistere sanitary region.

First step of the model derivation will consist in multivariate analysis to extract the most pertinent variates associated with neurological outcome (evaluated using the CPC Score); Second step will consist in the use of artificial intelligence and machine-learning to derive the most discriminant score.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Cardiac Arrest Cardiovascular Diseases Cognition Disorders Cognitive Dysfunction Cognitive Impairment Heart Arrest Heart Diseases Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurologic Dysfunction Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Brest, Brest, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cardiac arrest requiring cardiopulmonary resuscitation

Exclusion criteria

  • Death before cardiopulmonary resuscitation
  • Pediatric Patients

Treatment and study plan

Primary outcomes

  1. Cognitive Outcome

    Time frame: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 24 months

    It will be evaluated at the end of the ICU stay using the CPC score; a CPC score equal or below 2 will be considered as a good outcome, while a CPC > 2 will be considered as a bad outcome

Secondary outcomes

  1. Death OoH

    Time frame: Before hospital arrival

    Death after resuscitation during the prehospital care phase

  2. Death ICU

    Time frame: During ICU stay

    Death within the ICU care

  3. Death at Day 28

    Time frame: 28 days after cardiac arrest

    Death at Day 28, before or after hospital discharge

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Identification of Neuroprognostic Factors for Out-of-hospital Cardiopulmonary Arrest in the North Finistère Population: Derivation and Validation of a Predictive Score

Acronym: MIRA29

Important dates

Study start
2022
Primary completion
2023
Study completion
2025
First posted
Aug 23, 2024
Registry last updated
Aug 23, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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