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NCT Number: NCT06826586

Identification of Microplastics in Liver, Stomach, Blood, and Feces of Obese Patients and Their Association Analysis with Macrogenomics and Metabolomics.

The aim of this study was to identify and quantify microplastics in the stomach, liver, feces, and blood of obese patients to be treated with bariatric surgery by using a variety of advanced analytical techniques to explore the association between obesity and visceral microplastics, and to investigate the effects of microplastics on the visceral microbiota and metabolic profiles of obese patients by combining the macro-genomic and metabolomics approaches.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Obesity and Overweight Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years old;
  • BMI ≧30;
  • proposed to undergo bariatric surgery and need to remove part of the liver tissue for fatty liver test;
  • complete clinical data and basic information;
  • willing to participate in the study and sign the informed consent form.

Exclusion criteria

  • Receive chemotherapy, radiotherapy, immunotherapy;
  • have other history of digestive diseases;
  • combined with malignant tumors;
  • have serious cardiorespiratory insufficiency and other systemic diseases that affect the choice of treatment plan;
  • not willing to participate in this study.

Treatment and study plan

Measuring the microplastics

Diagnostic Test

Measuring the type, nature, and abundance of microplastics in stomach, liver, feces, and blood

Primary outcomes

  1. Differences in microbial communities

    Time frame: From the diagnosis of obesity, through study completion, an average of 1 year.

    Differences in different microbial communities in the stomach, liver, feces, and blood of obese patients

Sponsors and collaborators

Lead sponsor

First Affiliated Hospital of Chongqing Medical University

Other

Registry information

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Feb 14, 2025
Registry last updated
Feb 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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