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Completed

NCT Number: NCT00608998

Identification of Cardiovascular Risk Factors Linked to Renal Failure Progression

The aim of this study is to appreciate the influence of renal failure progression on vasculopathy (coronary calcifications and left ventricular hypertrophy) and cardiovascular risk factors.

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Key information

Conditions

Chronic Renal Failure Cardiovascular Diseases Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Universitaire

Montpellier, 34295, France

About this study

The aim of this study is to appreciate the relationship between:

  • extension of coronary calcifications and chronic renal failure progression
  • extension of coronary calcifications and levels of osteoprotegerin (bone disease marker)
  • cardiovascular risk factors and coronary calcifications
  • cardiovascular risk factors and existence of cardiovascular diseases

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient who has signed the written consent form
  • Patient aged > 18 and < 90 years
  • Chronic renal failure defined by glomerular filtration rate (GFR)
  • group 1: GFR >90 mL/min with urinary biological abnormalities and GFR comprised between 90 and 60 mL/min
  • group 2: GFR comprised between 60 and 30 mL/min
  • group 3: GFR <30 mL/min but without dialysis therapy

Exclusion criteria

  • Chronic renal failure patient requiring dialysis therapy

Treatment and study plan

Primary outcomes

  1. description of osteoprotegerin levels according to chronic renal failure progression

    Time frame: inclusion

Secondary outcomes

  1. calcium score description according to chronic renal failure progression

    Time frame: inclusion

  2. osteoprotegerin description according to calcium score

    Time frame: inclusion

  3. relationship between cardiovascular risk factors and calcium score

    Time frame: inclusion

  4. relationship between cardiovascular risk factors and cardiovascular disease

    Time frame: inclusion

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Collaborators

  • Ministry of Health, France

Registry information

Official study title

Vascular Risk Factors and Coronary Calcifications in Chronic Renal Failure Patients: Identification of Specific Factors Linked to Renal Failure Progression

Acronym: Pre-HD

Important dates

Study start
2007
Primary completion
2011
Study completion
2011
First posted
Feb 6, 2008
Registry last updated
Mar 22, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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