Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients

The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients. Patient samples suitable for antibody cloning are selected based on seroprofiling for the respective allergens. The study aims at isolating lymphocytes from patients with potential allergen-neutralizing IgG in serum and to clone antibodies from antibody gene sequences obtained from B cells of those patients.

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Key information

Conditions

Pollen Allergy Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Nose Diseases Otorhinolaryngologic Diseases Respiratory Hypersensitivity Respiratory Tract Diseases Rhinitis Rhinitis, Allergic Rhinitis, Allergic, Seasonal

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Immunologie Zentrum Zürich

Zurich, Canton of Zurich, 8006, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

History of allergic rhinitis, conjunctivitis or asthma due to sensitization to grass- or birch Allergens
Male or female patients older than 18 years
Written informed consent for providing blood and also to allow experimental manipulation

Exclusion criteria

Age < 18 years
Any corticosteroids within the last three days
Oral corticosteroid therapy within the last ten days
Parenteral depot corticosteroids within the last three months

Treatment and study plan

blood withdrawal

Other

Blood withdrawal

Primary outcomes

Antibody profiling

Time frame: October 2018 - September 2021

Analysis and IgG profiling of specific antibodies binding major grass- and tree-pollen allergens in allergic patients.

Sponsors and collaborators

Lead sponsor

Mabylon AG

Industry

Registry information

Important dates

Study start: 2018
Primary completion: 2025
Study completion: 2025
First posted: Nov 1, 2018
Registry last updated: May 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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