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Completed

NCT Number: NCT01644942

Identification in Obese Patients of the Mechanism Involved in Intramuscular Lipid Accumulation

The study aims to determine in obese patients the implication of intramuscular lipid accumulation in relation with insulin resistance and defect in lipid oxidation.

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Key information

Conditions

Obesity Body Weight Dyslipidemias Glucose Metabolism Disorders Hyperinsulinism Hyperlipidemia Hyperlipidemias Insulin Resistance Lipid Metabolism Disorders Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

40 year–70 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

CHRU Montpellier

Montpellier, 34295, France

About this study

Obese insulin sensitive and obese insulin resistant patients undergo a glucose tolerance test, indirect calorimetry during exercise and muscular biopsy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obese patients with a Body Mass Index (BMI) between 30 and 40 kg/m2
  • Patients who do not practice physical exercise (Voorips index < 9)
  • Age between 40 and 70 years- Male gender
  • Fast blood glucose <1,10 g/l and no hypoglycemic treatment
  • Signed informed consent
  • Social security affiliation
  • Absence of anti VIH, anti hepatitis C antibodies, and HBS antigen
  • Normal biological tests
  • Non smoking persons

Exclusion criteria

  • Patients who refuse the anti-VIH, anti-hepatitis C antibodies, and HBS antigens tests
  • Patients treated by anticoagulant, b blockers, lipopenic, or anti-inflammatory.
  • Patients with a contraindication to muscular exercise (retinopathy, coronaropathy, nephropathy) and to muscular biopsy
  • Allergy to local anaesthetic

Treatment and study plan

Lipid accumulation analysis

Other

The lipid accumulation will be assessed with muscular biopsies.

Primary outcomes

  1. lipid accumulation in skeletal muscle

    Time frame: 1 month

Secondary outcomes

  1. lipid accumulation in myotubes from obese patients

    Time frame: 1 month

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Official study title

Identification in Obese Patients of the Mechanisms Involved in Intramuscular Lipid Accumulation.

Important dates

Study start
2008
Primary completion
2013
Study completion
2013
First posted
Jul 19, 2012
Registry last updated
Jun 18, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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