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Completed

NCT Number: NCT00128518

IDEAL Study: Identification of the Determinants of the Efficacy of Arterial Blood Pressure Lowering Drugs

The principal scientific objective of the trial is to identify the factors that are associated with differential blood pressure responses between drugs. This may allow investigators to produce new hypotheses on the pathophysiology of hypertension and on the mechanisms of drug action.

These factors can be of different types:

* Environmental factors (sodium or alcohol intake); * Morphological (height, weight, body mass index, body surface area); * Initial blood pressure; * Electrocardiogram (ECG) parameters of left ventricular hypertrophy; * Biological parameters as the activity level of the renin angiotensin aldosterone system; * Genetic polymorphisms.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

25 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Hôpital Louis Pradel

Bron, 69677, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants have to be 25 to 60 years of age
  • Both genders
  • Systolic blood pressure of 140 mmHg or above; diastolic blood pressure of 90 mmHg or above.
  • Cardiovascular risk must not be high, to allow for two periods of 4 weeks of placebo without ethical concern.

Treatment and study plan

Indapamide (T2)

Drug

1.5 mg/day during 4 weeks

Perindopril (T1)

Drug

4 mg/day during 1 week then 8 mg/day during 3 weeks

Placebo of Perindopril (P1)

Drug

1 pill/day during 1 week then 2 pills/day during 3 weeks

Placebo of Indapamide (P2)

Drug

1 pill/day during 4 weeks

Primary outcomes

  1. Blood pressure at the end of each 4 week treatment period

    Time frame: 16 weeks

    Change from baseline and after each 4 week treatment period

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

IDEAL Study : Identification of the Determinants of the Efficacy of Arterial Blood Pressure Lowering Drugs

Important dates

Study start
2004
Primary completion
2010
Study completion
2010
First posted
Aug 10, 2005
Registry last updated
Dec 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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