Ideal Sedation for Stroke Thrombectomy

The Ideal Sedation for Stroke Thrombectomy (ISST) registry will answer the key questions whether sedation with intubation and paralytics is feasible and whether it delays the time to recanalization in comparison with conscious sedation alone. As a pilot registry, it is anticipated to enroll 40 acute stroke patients requiring mechanical thrombectomy over 12-18 months. Following enrollment, data will be collected prospectively from medical records and from patients' visits.

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Key information

Conditions

Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Los Robles Hospital and Medical Center

Thousand Oaks, California, 91360, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 years
Suitable for intra-arterial treatment for acute stroke up to 8 hours from onset of symptoms
Clinical equipoise for best mode of sedation

Exclusion criteria

Any known allergy to either proposed medication and its alternative
Any patient that has been intubated prior to randomization
Posterior circulation strokes
Age ≤ 18
Pregnant female

Treatment and study plan

Primary outcomes

Time interval between groin puncture and final recanalization

Time frame: 6 months or at study completion

Sponsors and collaborators

Lead sponsor

Dr. M. Asif Taqi

Other

Registry information

Acronym: ISST

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2018
First posted: Jan 30, 2017
Registry last updated: Jul 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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