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Completed

NCT Number: NCT07369206

ICU Admission Diagnoses and ICU Mortality

This retrospective cohort study will evaluate whether syndromic clinical diagnoses present at ICU admission are associated with ICU mortality, independent of physiologic severity scores. Adult patients admitted to a tertiary mixed ICU during 2025 will be assessed.

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Key information

Conditions

Critical Illness Acute Respiratory Distress Syndrome (ARDS) Acute Respiratory Failure Disease Attributes Infections Inflammation Lung Diseases Multiple Organ Dysfunction Syndrome Multiple Organ Failure Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases Sepsis Septic Shock Shock Shock, Septic Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ataturk University

Erzurum, 25240, Turkey (Türkiye)

About this study

Data will be obtained retrospectively from the hospital information system and ICU clinical records. Variables will be recorded based on the first 24 hours after ICU admission. Demographics, admission characteristics, comorbidities, severity scores (APACHE II, SAPS, SOFA), and admission syndromic diagnoses (e.g., sepsis/septic shock, acute respiratory failure, ARDS, MODS) will be collected. The primary outcome is ICU mortality; secondary outcomes include ICU length of stay and ICU discharge disposition.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (≥18 years) admitted to the ICU between January 1, 2025 and December 31, 2025.
  • If a patient has more than one ICU admission during the study period, only the first ICU admission will be included.

Exclusion criteria

  • ICU stay <24 hours.
  • Missing essential data preventing assessment of the primary outcome (ICU mortality) and/or calculation of severity scores (APACHE II, SAPS, SOFA).

Treatment and study plan

Primary outcomes

  1. ICU mortality

    Time frame: From ICU admission until ICU discharge (end of index ICU stay), assessed up to 90 days

    Death occurring during the index ICU stay (ICU mortality), abstracted from electronic medical records.

Secondary outcomes

  1. ICU length of stay (LOS)

    Time frame: From ICU admission to ICU discharge (index ICU stay), assessed at ICU discharge (up to 90 days)

    ICU length of stay (days) during the index ICU admission, calculated as the difference between ICU admission and ICU discharge timestamps in the electronic medical record.

  2. ICU discharge disposition

    Time frame: At ICU discharge (index ICU stay; assessed at the time of ICU discharge in the medical record, up to 90 days)

    Disposition at ICU discharge categorized as: death in ICU, transfer to hospital ward, or transfer to another facility; determined from the ICU discharge documentation in the electronic medical record.

Sponsors and collaborators

Lead sponsor

Ataturk University

Other

Registry information

Official study title

Association of Admission Syndromic Diagnoses With ICU Mortality in a Mixed Adult Intensive Care Unit: Retrospective Cohort

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jan 27, 2026
Registry last updated
Feb 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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