Iatrogenic Deficiencies in ICU Patients With Prolonged Continuous Renal Replacement Therapy

ICU patients are recruited after at least 5 days treatment with continuous renal replacement therapy. Blood samples are drawn at time of recruitment and then every 3-5 days until ceseation of renal replacement therapy.

Samples will be analyzed for concentrations of trace elements, vitamins and amino acids.

10 adult ICU patients treated for two weeks without renal replacement therapy will be sampled at one time point to serve as controls.

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

CRRT group:

CRRT more than 5 days

Exclusion criteria

Inclusion criteria

non-CRRT group

ICU care 10-15 days without any dialysis treatment

Treatment and study plan

Blood test

Diagnostic Test

Blood samples are drawn every 3-5 days in the RRT group but only once in the control group

Primary outcomes

Concentration of trace element

Time frame: From enrollment to the end of treatment at 4 weeks

Measurments of trace elements and vitamins as compared to established reference values as well as non-CRRT controls

Secondary outcomes

Amino acids

Time frame: From enrollment to the end of treatment at 4 weeks

Concentration of amino acids in plasma
Vitamins

Time frame: At all measuring points

Water soluble vitamins, concentration in plasma. Compared to non-crrt controls and established references

Study contacts

Contact information is provided by the study sponsor or research team.

Jonathan Grip, MD, PhD

CONTACT

[email protected]

+46 73 623 09 06

Kristina Kilsand, Research nurse

CONTACT

[email protected]

+46 8 123 810 03

Sponsors and collaborators

Lead sponsor

Karolinska University Hospital

Other

Registry information

Official study title

Iatrogena bristtillstånd Hos intensivvårdade Patienter Under långvarig Behandling Med Kontinuerlig Dialys

Acronym: IBRIST

Important dates

Study start: 2025
Primary completion: 2028
Study completion: 2029
First posted: May 21, 2025
Registry last updated: May 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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