I125 Brachytherapy After TURP

Inclusion criteria

• WHO performance status 0-1
• No contra-indication for anaesthesia
• No history of irradiation of the pelvis
• No other oncologic malignancy except adequately treated basal cell carcinoma of the skin or other malignancy from which the patient is disease free for at least 5 years.
• Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule;

Prostate (cancer) related:

• Histologically proven prostate cancer (adenocarcinoma) of low or intermediate risk following the D'Amico classification.
• Prostate volume < 50 cc as measured on transrectal ultrasound
• Neo-adjuvant antiandrogen hormonal treatment is permitted to downsize the prostate volume or to cover waiting time till brachytherapy procedure. No adjuvant hormonal treatment is permitted.
• History of TransUrethral Resection of the prostate (TURp), performed at least 3 months before the brachytherapy procedure.
• Rim of prostate tissue of at least 1 cm around the post-TURp urethral defect at thepostero-lateral sides of the prostate
• Absence of significant TURp-induced urinary incontinence
• IPSS <15

Exclusion criteria

• Locally advanced (stage T3 or T4 , or metastatic (stage N+ or M+) prostate cancer High grade tumours defined by Gleason score 8 or above Co-morbidity which would exclude the patient from a transperineal implant procedure.

Unable to give informed consent.