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Completed

NCT Number: NCT07018817

Hypoxia Adaptation Promotes Cerebral Functional Connectivity With Neuromuscular Efficiency Decrement

The study utilized a trimodal setup comprising EEG, EMG, and fNIRS modules. Participants wore a 64-channel dry EEG cap, while EMG electrodes were placed on the right biceps brachii, the flexor digitorum profundus of the forearm, and the gastrocnemius muscle. fNIRS probes were positioned on the forehead to monitor cerebral hemodynamic responses.

The experimental paradigm included two tasks: motor execution (ME) and motor imagery (MI). During ME, participants performed 15 trials of actual movements. In MI, participants completed 60 trials of imagined movements. Each trial involved a randomly presented stimulus-left-hand clenching, right-hand clenching, or bilateral heel raising-with each movement type occurring an equal number of times across the session.

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Key information

Conditions

Hypoxia Altitude Sickness Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Sex eligibility

All sexes

Study type

Observational

Primary location

Institute of Biomedical engineering，Chinese Academy of Medical Sciences & Peking Union Medical College

Tianjin, Tianjin Municipality, 300000, China

About this study

This study employed a multimodal acquisition system comprising EEG, EMG, and fNIRS modules. Participants were fitted with a 64-channel dry EEG cap for the measurement of cortical electrical activity. Surface EMG electrodes were attached to three muscle groups: the right biceps brachii, the flexor digitorum profundus of the forearm, and the gastrocnemius muscle, to record muscle activation signals. Simultaneously, fNIRS probes were positioned on the participants' foreheads to monitor cerebral hemodynamic responses.

The experimental paradigm was divided into two tasks: motor execution (ME) and motor imagery (MI). During the ME task, participants performed 15 trials of actual movements, whereas the MI task involved 60 trials of imagined movements. Each trial randomly presented one of three stimuli-left-hand clenching, right-hand clenching, or bilateral heel raising-with an equal distribution of the three movement types across the session. The order of stimuli was randomized to prevent prediction bias.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • People who can withstand altitude sickness

Exclusion criteria

  • Plateau Native

Treatment and study plan

motor execution motor imagery

Behavioral

Participants will perform motor execution tasks and motor imagery tasks following standardized instructions under controlled conditions.

Primary outcomes

  1. EEG Power Spectrum in Motor Imagery and Motor Execution Tasks

    Time frame: up to 2 weeks

Secondary outcomes

  1. Surface EMG Amplitude of Upper Limb Muscles during Motor Tasks

    Time frame: up to 2 weeks

  2. Cerebral Oxygenation Measured by Near-Infrared Spectroscopy (NIRS) in Prefrontal Cortex

    Time frame: up to 2 weeks

Sponsors and collaborators

Lead sponsor

Peking Union Medical College

Other

Registry information

Official study title

A Trimodal Study on Hypoxia Adaptation: Promotion of Cerebral Functional Connectivity and Decrement of Neuromuscular Efficiency

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jun 13, 2025
Registry last updated
Jun 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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