Skip to main content
OpenTrials
Completed

NCT Number: NCT00214123

Hypofractionated Radiotherapy for Lung Cancer

The purpose of this trial is to pilot reducing the duration of radiation treatment for lung cancer patients from 6 to 5 weeks using tomotherapy. Specific patient doses will be based on tumor volume being treated. Modeling has shown that increased biologically effective dose (BED) to tumors can be achieved by shortening the radiation delivery schedule and increasing the dose per fraction. This requires decreasing the total dose to hold lung toxicity constant at each dose per fraction level. This is a major paradigm shift in the treatment in this disease and is projected to result in significant improvements in patient outcome as well as a substantial cost savings.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Thoracic neoplasm requiring at lest 60 Gy conventional radiotherapy

Exclusion criteria

  • Prior bleomycin or gemcitabine chemotherapy
  • Prior thoracic radiotherapy

Treatment and study plan

radiation therapy (radiotherapy)

Radiation

Bin assignment based on tumor volume

Primary outcomes

  1. Grade 3 pneumonitis lasting greater than 2 weeks

    Time frame: 90 days post radiotherapy (XRT)

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Registry information

Official study title

The Use of Helical Tomotherapy to Achieve Dose-per-fraction Escalation in Lung Cancer

Important dates

Study start
2004
Primary completion
2012
Study completion
2012
First posted
Sep 21, 2005
Registry last updated
Dec 13, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.