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NCT Number: NCT07518498

Hypnosis During Mechanical Ventilation Weaning

Hypnosis is defined as an altered state of consciousness characterized by an increased susceptibility to suggestion. It is a technique commonly used in the medical field, primarily for the management of pain and anxiety.

The literature demonstrates that better pain management is correlated with a shorter length of stay in the ICU and a shorter duration of mechanical ventilation.

In patients hospitalized in the ICU requiring invasive mechanical ventilation, the emotional component plays a significant role in dyspnea, which can become an obstacle to weaning from ventilation. The analgesic and anxiolytic treatments used carry numerous side effects and contraindications, limiting their use in ICU patients. Furthermore, pulmonary edema is a common cause of failure to wean from invasive mechanical ventilation. By reducing the occurrence of hypertension and tachycardia, hypnosis could be used as a therapeutic strategy to limit its incidence. Thus, hypnosis could be a valuable therapeutic tool for improving tolerance and the success of ventilator weaning.

Although hypnosis is already commonly used in intensive care units, its use is still limited by a lack of evidence for more specific indications. It is in this context that this study was conducted, to assess the feasibility of conducting a hypnosis session during weaning from invasive mechanical ventilation in the intensive care unit.

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Key information

Conditions

Hypnosis Hypnosis During Weaning From Invasive Mechanical Ventilation Weaning Mechanical Ventilation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 and older
  • Patients hospitalized in the intensive care unit and requiring invasive mechanical ventilation for at least 48 hours
  • Presence of the prerequisite criteria for ventilator weaning: effective cough, minimal bronchial congestion, patient awake and not agitated, hemodynamic stability (heart rate less than 140 beats per minute, systolic blood pressure between 90 and 160 mmHg without vasopressors), pressure support ventilation, FiO2 < 40% and PEEP ≤ 8 cmH2O, PaO2/FiO2 > 150, pH > 7.35, respiratory rate < 35 per minute
  • Patients enrolled in a social security program or eligible for such a program
  • Patients who has received complete information about the clinical research protocol and has signed an informed consent form
  • Patients who has undergone a preliminary clinical examination appropriate for the clinical research

Exclusion criteria

  • Contraindication to hypnosis (particularly severe psychotic disorders)
  • Non-French-speaking individuals
  • Deaf or hard-of-hearing individuals
  • State of agitation or acute delirium
  • Individuals who have already undergone a spontaneous ventilation test or an attempt at orotracheal extubation during their hospitalization
  • Individuals receiving a new anxiolytic or sedative treatment within 2 hours prior to the weaning test
  • Individuals with a tracheostomy
  • Women of childbearing age who do not have access to effective contraception
  • Individuals covered by Articles L. 1121-5, L. 1121-7, and L. 1121-8 of the Public Health Code (pregnant women, women in labor, or breastfeeding women, minors not emancipated, adult subject to a legal protection measure, adult unable to give consent)
  • Person deprived of liberty by a judicial or administrative decision, or a person receiving psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1

Treatment and study plan

hypnosis

Behavioral

The intervention consists of a standardized hypnosis session delivered by a trained practitioner during the weaning phase from invasive mechanical ventilation in an intensive care unit.

Primary outcomes

  1. Feasibility of a hypnosis session during weaning from invasive mechanical ventilation.

    Time frame: At the end of the recruitment period

    Number of hypnosis sessions conducted, relative to the number of eligible patients.

Secondary outcomes

  1. Progression of pain and anxiety during weaning from invasive mechanical ventilation using hypnosis.

    Time frame: During the hypnosis session (Day 1)

    Assessment of pain and anxiety using visual analog scales before and after the hypnosis session.

  2. Frequency of failed weaning from invasive mechanical ventilation among patients who underwent a hypnosis session.

    Time frame: During ICU stay

    Ventilator weaning failure rate.

  3. Complications associated with weaning from mechanical ventilation using hypnosis.

    Time frame: During the ICU stay

    Number and types of complications.

  4. Length of stay in the intensive care unit following weaning from mechanical ventilation using hypnosis.

    Time frame: ICU stay

    Length of stay in the intensive care unit.

  5. Mortality following weaning from mechanical ventilation using hypnosis.

    Time frame: At day 28

    Death rate

  6. Patients' experiences

    Time frame: On the day of discharge from the ICU, and no later than Day 28

    Form for patients who received hypnosis during weaning from mechanical ventilation.

  7. Professionals' perceptions of hypnosis

    Time frame: Throughout the study's enrollment period.

    Form for healthcare professionals who have conducted at least one hypnosis session.

Study contacts

Contact information is provided by the study sponsor or research team.

Sébastien Gibot, MD

CONTACT

[email protected]

+ 33 383851495

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Collaborators

  • Centre Hospitalier Régional Metz-Thionville

Registry information

Official study title

Hypnosis During Mechanical Ventilation Weaning : Feasibility and Physiological Impact

Acronym: HYPREA

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 8, 2026
Registry last updated
Apr 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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