Hypertrophic Cardiomyopathy Pilot Study

This study evaluates mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from arrhythmogenic substrate

Completed

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Key information

Conditions

Hypertrophic Cardiomyopathy Aortic Stenosis, Subvalvular Aortic Valve Disease Aortic Valve Stenosis Arterial Occlusive Diseases Arteriosclerosis Cardiomyopathies Cardiomyopathy, Hypertrophic Cardiovascular Diseases Coronary Artery Disease Coronary Disease Heart Diseases Heart Valve Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Oregon Health and Science University

Portland, Oregon, 97239, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosed HCM
Documented history of sustained ventricular tachyarrhythmia or resuscitated sudden cardiac arrest
Maximal left ventricular wall thickness of > 30mm
Extensive fibrosis on cardiac MRI (>15% of total myocardial volume)
>7.5%/5-year risk of sudden cardiac death as determined by HCM risk-SCD

Exclusion criteria

age < 18 years
Pregnancy
Atrial Fibrillation

Treatment and study plan

Observational: Arrhythmogenic Substrate

Other

Primary outcomes

Non-invasively reconstructed epicardial activation map

Time frame: within one day

Sponsors and collaborators

Lead sponsor

Oregon Health and Science University

Other

Registry information

Official study title

Pilot Observational Case-control Study of the Electrical Heterogeneity in Patients With Hypertrophic Cardiomyopathy and High Arrhythmic Risk

Important dates

Study start: 2016
Primary completion: 2020
Study completion: 2020
First posted: Jun 20, 2016
Registry last updated: Sep 16, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed