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Completed

NCT Number: NCT06824805

Hypertension, Ethnicity and Exercise Trial

The main aim of this study is to investigate the acute effects of a single bout of isometric handgrip exercise (IHG) and a single bout of aerobic endurance exercise (AEX) on blood pressure, both immediately after exercise and during the subsequent activities of daily living in patients with high-normal to grade 1 hypertension of South-Asian or African descent living in Suriname.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Anton De Kom University

Paramaribo, Suriname

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Age 18 - 65 years
  • Patients with high- normal BP (SBP: 130 - 139 mmHg or and DBP: 85 - 89 mmHg) or stage I hypertension (SBP: 140 - 159 mmHg or DBP: 90 - 99 mmHg) according to the ESC/ESH guidelines [15]
  • Asian or African descent
  • Do not meet the level of physical activity recommended by the WHO based on self-report [15]
  • Non-medicated patients or patients using a maximum of 2 antihypertensive drugs

Exclusion criteria

  • • Functional or mental limitation limiting the correct execution of an exercise bout
  • History of ischemic stroke, autonomic neuropathy, cardiovascular, renal, or pulmonary disease by self-report
  • Diabetes type I or II
  • Pregnancy
  • The presence of exercise induced signs of myocardial ischemia or complex ventricular arrhythmia during CPET
  • Patients using three or more antihypertensive drugs or patients with resistant hypertension

Treatment and study plan

Exercise

Behavioral

aerobic exercise for 30 minutes at 40-60% HRres

Primary outcomes

  1. office blood pressure at 30 minutes post exercise

    Time frame: 30 minutes postexercsie

    office blood pressure at 30 minutes post exercise

Secondary outcomes

  1. daytime blood pressure

    Time frame: mean of 8 hours after the intervention

    daytime ambulatory blood pressure (8 hours after the intervention)

Sponsors and collaborators

Lead sponsor

KU Leuven

Other

Registry information

Acronym: HYPE2X

Important dates

Study start
2020
Primary completion
2023
Study completion
2023
First posted
Feb 13, 2025
Registry last updated
Feb 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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