Skip to main content
OpenTrials
Completed

NCT Number: NCT04019002

Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma

The purpose of this study is to evaluate whether new metabolic imaging will be useful to physicians and patients with glioblastoma for making treatment decisions and seeing how well various types of treatment work. The goal is to improve the way patient care is managed in the future.

If you chose to be in this study, you will be receiving novel magnetic resonance (MR) metabolic imaging with standard MR imaging. The research component includes an injection of an investigational agent, called hyperpolarized 13C pyruvate, to obtain dynamic metabolic imaging.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Glioblastoma Multiforme (GBM) Astrocytoma Glioblastoma Glioma Neoplasms Neoplasms by Histologic Type Neoplasms, Germ Cell and Embryonal Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neoplasms, Neuroepithelial Neuroectodermal Tumors

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

University of California, San Francisco

San Francisco, California, 94143, United States

About this study

The new metabolic imaging will use hyperpolarized 13C pyruvate, which allows for pictures of the brain that we won't be able to get with standard imaging. Hyperpolarized 13C pyruvate has not been approved for use by the Food and Drug Administration (FDA) and is available for research only. This investigational agent is a non-radioactive isotope of carbon.

There are three groups in this study. Assignment to a study group depends on the status of your disease and the type of treatment you will be receiving.

Subjects in Group 1 will have two MR examination time points. Each time point includes a hyperpolarized 13C pyruvate injection for research imaging as well as standard MR. The MR examinations will occur before receiving standard of care treatment with radiation and chemotherapy, and at the first post-radiation follow-up scan.

Subjects in Group 2 will have one MR examination time point with hyperpolarized 13C pyruvate injection for research and standard MR. This MR examination occurs before surgery.

Subjects in Group 3 will have three MR examination time points. Each time point includes a hyperpolarized 13C pyruvate injection for research imaging as well as standard MR. The MR examinations will occur prior to initiating therapy (baseline), at approximately 7-14 days after initiation of therapy, and 6-8 weeks after the initiation of therapy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cohort 1: Histologically proven newly diagnosed glioblastoma multiforme (GBM) who will undergo standard of treatment with radiation therapy (RT) and temozolomide (TMZ).
  • Cohort 2: Histologically proven recurrent suspected GBM who will receive surgical resection for the recurrence.
  • Cohort 3: Histologically proven recurrent suspected GBM who will undergo standard treatment for the recurrence.
  • Patients must be >/= 18 years old and with a life expectancy > 16 weeks.
  • Patients must have a Karnofsky performance status of ≥ 70.
  • Patients must have adequate renal function: creatinine < 1.5 mg/dL before imaging. These tests must be performed within 60 days prior to Hyperpolarized Imaging scan.
  • Patients must not have any significant medical illnesses that in the investigator's opinion cannot be adequately controlled with appropriate therapy, would compromise the patient's ability to tolerate the imaging examination or any disease that will obscure toxicity or dangerously alter response to the imaging agent.
  • Patients must not have New York Heart Association (NYHA) Grade II or greater congestive heart failure
  • Patients must not have a history of myocardial infarction or unstable angina within 12 months prior to study enrollment.
  • This study was designed to include women and minorities, but was not designed to measure differences of intervention effects. Males and females will be recruited with no preference to gender. Minorities will actively be recruited to participate. No exclusion to this study will be based on race.
  • Patients must sign an informed consent indicating that they are aware of the investigational nature of this study. Patients must sign an authorization for the release of their protected health information.
  • Patients may not be known to be human immunodeficiency virus (HIV)-positive. HIV testing is not required for study participation.
  • Patients must not have a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix), unless in complete remission and off of all therapy for that disease for a minimum of 3 years.
  • Patients must not be pregnant or breast feeding. Women of childbearing potential are required to obtain a negative pregnancy test within 14 days of Hyperpolarized Imaging scan. Effective contraception (men and women) must be used in subjects of child-bearing potential.

Exclusion criteria

  • Subjects must be excluded from participating in this study if they are not able to comply with study and/or follow-up procedures.

Treatment and study plan

Hyperpolarized 13C Pyruvate

Drug

Given at 0.43 milliliters/kilogram body weight of a 250 millimolar (mM) solution via intravenous injection over a period of about 1 minute once prior to each research magnetic resonance imaging procedure.

Other names: HP-13C

Primary outcomes

  1. Number of Treatment Emergent Adverse Events (AEs) Assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0

    Time frame: From Day 1 through study completion, up to 4 months

    Patients will be monitored for the occurrence of AEs that occur during the course of study participation. AE monitoring occurs on each day of hyperpolarized 13C pyruvate administration and until 7 days after administration. Serious adverse events occurring more than 7 days after administration need only be reported if relationship to the investigational drug is suspected.

  2. Number of Dose-Limiting Toxicities (DLTs) Assessed by CTCAE Version 4.0

    Time frame: From Day 1 through study completion, up to 4 months

    A DLT for this protocol is defined as any event grade 3 or higher in severity assessed by CTCAE version 4.0 that is possibly, probably, or definitely attributable to the investigational drug, excluding laboratory abnormalities determined to be clinically insignificant.

  3. Describe Changes in 13C pyruvate-to-lactate conversion rate (kPL) in Normal and Diseased Brain Tissues

    Time frame: Day 1 and Week 8

    The changes in 13C kPL from baseline to the post-RT scan will be compared in the normal appearing brain, enhancing lesion, and non-enhancing lesion

  4. Describe Changes in 13C Lactate/Pyruvate Ratio in Normal and Diseased Brain Tissues

    Time frame: Day 1 and Week 8

    The changes in 13C lactate/pyruvate ratio from baseline to the post-RT scan will be compared in the normal appearing brain, enhancing lesion, and non-enhancing lesion

  5. Compare 13C kPL Between Recurrent Lesions and Regions of Treatment Related Effects

    Time frame: Day 1, Week 1-2, and Week 6-8

    The 13C kPL from the recurrent lesions will be compared to those in the regions of treatment related effects.

  6. Compare 13C Lactate/Pyruvate Ratio Between Recurrent Lesions and Regions of Treatment Related Effects

    Time frame: Day 1, Week 1-2, and Week 6-8

    The 13C lactate/pyruvate ratio from the recurrent lesions will be compared to those in the regions of treatment related effects.

  7. Determine the Association Between 13C kPL and Time to Disease Progression

    Time frame: From Day 1 until the date of documented disease progression, an average of 1 year

    Relationships between 13C kPL and time to disease progression will be compared. Time to disease progression is defined as the time from first study imaging until worsening of glioblastoma disease.

  8. Determine the Association Between 13C Lactate/Pyruvate Ratio and Time to Disease Progression

    Time frame: From Day 1 until the date of documented disease progression, an average of 1 year

    Relationships between 13C lactate/pyruvate ratio and time to disease progression will be compared. Time to disease progression is defined as the time from first study imaging until worsening of glioblastoma disease.

  9. Determine the Association Between Hydrogen-1 (1H) Choline-to-N-acetylaspartate (NAA) index (CNI) and Time to Disease Progression

    Time frame: From Day 1 until the date of documented disease progression, an average of 1 year

    Relationships between 1H CNI time to disease progression will be compared. Time to disease progression is defined as the time from first study imaging until worsening of glioblastoma disease.

  10. Determine the Association Between 13C kPL and Overall Survival

    Time frame: From Day 1 until the date of death from any cause, up to 2 years

    Relationships between 13C kPL and overall survival will be compared. Overall Survival is defined as the time from first study imaging until death from any cause.

  11. Determine the Association Between 13C Lactate/Pyruvate Ratio and Overall Survival

    Time frame: From Day 1 until the date of death from any cause, up to 2 years

    Relationships between 13C lactate/pyruvate ratio and overall survival will be compared. Overall Survival is defined as the time from first study imaging until death from any cause.

  12. Determine the Association Between 1H CNI and Overall Survival

    Time frame: From Day 1 until the date of death from any cause, up to 2 years

    Relationships between 1H CNI and overall survival will be compared. Overall Survival is defined as the time from first study imaging until death from any cause.

Sponsors and collaborators

Lead sponsor

Susan Chang

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

Evaluating Hyperpolarized and Proton Brain Metabolism in Patients With Glioblastoma

Important dates

Study start
2019
Primary completion
2025
Study completion
2025
First posted
Jul 15, 2019
Registry last updated
Mar 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.