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NCT Number: NCT05766384

Hyperpolarized 129Xe MRI Lung Health Cohort

A subset of young adults participating in the American Lung Association (ALA) Lung Health Cohort (LHC) will be imaged using Hyperpolarized 129Xe MRI to assess lung structure and function. Images will be used to improve the understanding of lung health and early lung abnormalities that may lead to chronic lung disease.

Recruiting

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Key information

Conditions

Healthy

Age range

25 year–35 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Illinois-Chicago, Chicago, Illinois, United States

Loading trial locations.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Is enrolled in the American Lung Association Lung Health Cohort Study.
  • Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date.

Exclusion criteria

  • Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, > 140 cm shoulder circumference, dependent on weight distribution).
  • Is pregnant or breastfeeding
  • Oxygen saturation (SpO2) <88% on room air or with supplemental oxygen.

Treatment and study plan

Hyperpolarized Xe129

Drug

Inhaled hyperpolarized 129Xe used as a signal agent for MRI of the lungs.

Other names: Xenon, 129Xe, HP Xenon

Primary outcomes

  1. Xe-MRI Apparent Diffusion Coefficient

    Time frame: At baseline imaging timepoint

    Correlation of Xe-MRI with FEV1/FVC and other measures of lung function

Study contacts

Contact information is provided by the study sponsor or research team.

Cristal Monge

CONTACT

[email protected]

913-945-9399

Sponsors and collaborators

Lead sponsor

University of Kansas Medical Center

Other

Collaborators

  • Baylor College of Medicine
  • Duke University
  • Johns Hopkins University
  • Temple University
  • University of Illinois at Chicago
  • University of Iowa
  • University of Pennsylvania

Registry information

Official study title

Hyperpolarized 129Xe MRI to Identify Structural Determinants of Low Lung Function and Respiratory Symptoms in Young Adults From the Lung Health Cohort

Acronym: XeLHC

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Mar 13, 2023
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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