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Completed

NCT Number: NCT01793454

Hyperoxic Oxidative Stress During Abdominal Surgery

Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.

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Key information

Conditions

Response to Hyperoxia

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department

Istanbul, Fatih, 34400, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing abdominal surgery, between 20-60 years old, with American Society of Anesthesiology score I or II

Exclusion criteria

  • Patients with Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, muscle-bone diseases, inflammatory bowel diseases and patients with malnutrition.

Patients will be recruited through general surgery service of our hospital

Treatment and study plan

Fraction of inspired oxygen 40%

Other

Fraction of inspired oxygen 80%

Other

Primary outcomes

  1. oxidant and antioxidant response

    Time frame: 4 hours

    As primary outcome, the effects of different inspired oxygen fractions on oxidative stress and anti-oxidant response in plasma and bronchoalveolar lavage after intubation and prior to extubation will be evaluated

Secondary outcomes

  1. Hemodynamics

    Time frame: 4 hours

    The secondary outcome was evaluating the effects of different inspired oxygen fractions on hemodynamics.

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Official study title

Comparing the Effect of Hyperoxic and Conventional Fraction of Inspired Oxygen on Oxidative Stress During Abdominal Surgery.

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Feb 15, 2013
Registry last updated
Apr 9, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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