Skip to main content
OpenTrials
Completed

NCT Number: NCT03571074

Hyperoxia Before and After Cardiac Arrest and Myocardial Damage

Several studies show how patients with hyperoxia after cardiac arrest has increased mortality, but the association of hyperoxia before cardiac arrest and myocardial damage has never been investigated. Neither has the association between hyperoxia after cardiac arrest and myocardial injury.

Our research hypothesis is that hyperoxia before cardiac arrest aggravates myocardial damage, secondly we wish to analyze the association between hyperoxia after cardiac arrest and myocardial injury.

The exposure variables is oxygenation within 48 hours before and 48 hours after cardiac arrest, our primary outcome is myocardial damage and will be measured as peak troponin within 30 days after cardiac arrest.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Bispebjerg Hospital

Copenhagen, 2400, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years or older
  • With a record of ICD-10 diagnosis of cardiac arrest in 2014, admitted to a hospital in the Capital Region of Denmark.
  • First recorded cardiac arrest in 2014
  • Admitted to ICU
  • Serum troponin measured within 7 days after cardiac arrest

Exclusion criteria

  • Out of hospital cardiac arrest, OHCA
  • In of hospital cardiac arrest, IHCA, but with no registered saturation before cardiac arrest.

Treatment and study plan

Oxygenation

Other

Oxygenation measured as oxygen supply and saturation before cardiac arrest, and oxygenation measured as PaO2 after cardiac arrest.

Primary outcomes

  1. Peak troponin within 30 days after cardiac arrest

    Time frame: 30 days

    Troponin measurements on patients after cardiac arrest.

Secondary outcomes

  1. 30-day and 1-year mortality

    Time frame: Up to 1 year.

  2. Troponin area under the curve within 3 days after cardiac arrest

    Time frame: 3 days

  3. Length of ICU stay after cardiac arrest

    Time frame: through study completion,on average of 4-8 weeks.

  4. Length of hospital stay after cardiac arrest

    Time frame: through study completion,on average of 4-8 weeks.

Sponsors and collaborators

Lead sponsor

University Hospital Bispebjerg and Frederiksberg

Other

Registry information

Official study title

Hyperoxia Before and After Cardiac Arrest and Myocardial Damage, a Retrospective Cohort Study

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Jun 27, 2018
Registry last updated
Oct 23, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.