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NCT Number: NCT06820905

Hyperinflammation and Hyperferritinemia in Critically Ill Patients

Analysing trajectory of critically ill patients with signs of hyperinflammation

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Key information

Conditions

Critical Illness Disease Attributes Hyperferritinemia Hyperinflammatory Syndrome Infections Inflammation Iron Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of Medicine and Teaching Hospital, Charles University

Pilsen, Czech Republic, 30460, Czechia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • critically ill patients
  • admission between 01.01.2020 and 31.12.2024 (5yrs)

Exclusion criteria

  • none

Treatment and study plan

Primary outcomes

  1. hyperferritinemia

    Time frame: 2025

    trajectory of critically ill patients with significant hyperferritinemia and with regard to its dynamics; ferritin value cutt-off

Secondary outcomes

  1. etiology and association of hyperferritinemia

    Time frame: 2025

    etiology and association of hyperferritinemia with infectioius a non-infectious diseases/conditions

  2. mortality a morbidity

    Time frame: 2025

    mortality a morbidity of patients with significant hyperferritinemia

  3. treatment strategy

    Time frame: 2025

    association of hyperferritinemia and treatment strategy

  4. stratification

    Time frame: 2025

    patient stratification according to hyperferritinemia/hyperinflammation

Study contacts

Contact information is provided by the study sponsor or research team.

Thomas Karvunidis, MD, PhD

CONTACT

[email protected]

+420776160620

Sponsors and collaborators

Lead sponsor

Charles University, Czech Republic

Other

Registry information

Official study title

Hyperinflammation and Hyperferritinemia in Critically Ill Patients: a Retrospective Observational Single-center Analysis

Acronym: HYFER

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 11, 2025
Registry last updated
Feb 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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