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Completed

NCT Number: NCT04304339

Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg. Several physiopathological parameters such as respiratory minute volume, dead space volume or CO2 production influence the PaCO2. Therefore, hypercapnia can affect the time of various diseases.

Available epidemiological data regarding hypercapnia are from studies investigating the efficacy of non-invasive ventilation (NIV), with different population cohorts. However, their interpretation must be cautious given the heterogeneity in patient case-mix and results.

Then, whether hypercapnia is a common reason for intensive care unit (ICU) admission, epidemiological data is scarce and heterogeneous. The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.

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Key information

Conditions

Intensive Care Unit Syndrome Acute Respiratory Failure Hypercapnia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CH Andre Migniot, Versailles, A, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients ≥18 years old presenting with at least of the following items :
  • respiratory rate ≥ 25/min,
  • paradoxical motion of the abdomen,
  • intercostal retraction AND
  • a PaCO2 > 45 cm H20 before ICU admission or within the 12 hours following ICU admission.

Exclusion criteria

  • Refusal to give informed consent,
  • pregnancy,
  • < 18 years patient,
  • dying patient

Treatment and study plan

Hypercapnic respiratory failure

Other

Patients with hypercapnic respiratory failure will be followed without any additional intervention

Primary outcomes

  1. Prevalence of hypercapnic acute respiratory failure in ICU

    Time frame: Intensive Care Unit length stay (Usually 7 days)

    Number of patients with hypercapnic acute respiratory failure in ICU related to number of patients admitted in the ICU during study period

Sponsors and collaborators

Lead sponsor

French Society for Intensive Care

Other

Registry information

Acronym: YETI

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Mar 11, 2020
Registry last updated
Sep 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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