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NCT Number: NCT00528138

Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation

It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis.

The investigators believe, based on their own previous publications, that C-reactive protein (CRP) with or without a white blood cell count and some other clinical parameters, are more specific markers for the preoperative diagnosis of perforated acute appendicitis.

The purpose of this study is to prospectively compare the specificity and sensitivity of hyperbilirubinemia CRP, white blood cell count and other clinical parameters for the preoperative diagnosis of acute appendicitis.

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Key information

Conditions

Perforated Appendicitis Appendicitis Cecal Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Hyperbilirubinemia Infections Intestinal Diseases Intraabdominal Infections Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital De La Serena - Emergency Unit

La Serena, Coquimbo Region, IV Region, Chile

About this study

  • Previously validated appendicitis score
  • Time from onset of symptoms to diagnosis and to surgery
  • Laboratory values: WBC, CRP, liver function test
  • SIRS values
  • Preoperative and postoperative diagnosis
  • Length of hospital stay
  • Postoperative complications
  • Biopsy results

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled for appendectomies for acute appendicitis at the emergency unit of our institution
  • Patients older than 15 years of age to 100 years of age

Exclusion criteria

  • Appendectomy performed incidentally or for other indications
  • Patients younger than 15 years of age
  • Alcoholism
  • A history of viral hepatitis
  • Gilbert's disease
  • Dubin Johnson syndrome
  • BRIC (benign recurrent intra-hepatic cholestasis) and other documented biliary
  • Hemolytic or liver diseases associated with hyperbilirubinaemia

Treatment and study plan

Laboratory test

Other

CRP, white blood cell count, hepatic function tests

Sponsors and collaborators

Lead sponsor

Cirujanos la Serena

Other

Registry information

Official study title

Prospective Study Comparing Hyperbilirubinemia, CRP, White Blood Cell Count, and Other Clinical Parameters for the Preoperative Diagnosis of Perforated Acute Appendicitis

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Sep 12, 2007
Registry last updated
Nov 10, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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