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OpenTrials
Completed

NCT Number: NCT06889038

Hyperbaric Oxygen Therapy Combined With Polarized Light Therapy Effect on Neuropathic Foot Ulcer

Neuropathic ulcers develop due to nerve damage (neuropathy), commonly seen in conditions like diabetes, leading to loss of sensation, repetitive trauma, and poor wound healing. These ulcers typically occur on weight-bearing areas, hyperbaric oxygen and polarized light therapies may have a synergistic effect, improving oxygenation, cellular activity, and overall healing outcomes in neuropathic ulcers, particularly in diabetic foot ulcers.

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Key information

Conditions

Neuropathic Diabetic Ulcer - Foot

Age range

55 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Modern University For Technology and Information

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients had cardiac ejection fraction (CEF) 50%
  • blood pressure (BP) 150/90mmHg.
  • Chest X-ray was reported normal
  • all patients were clinically evaluated by a specialized ear, nose, and throat (ENT) physician to ensure suitability for the hyperbaric chamber.

Exclusion criteria

  • chronic obstructive pulmonary disease, malignancy
  • cardiac pacemakers, or any disorder that lead to ulcers other than diabetes
  • chronic peripheral arterial disease.

Treatment and study plan

Hyperbaric oxygen therapy combined with polarized light therapy

Other

Optimum regime of therapy increase healing rate of neuropathic foot ulcer is a challenge for researchers to save patient normal life

traditional treatment

Other

topical medication

Primary outcomes

  1. Ulcer volume using Saline injection method

    Time frame: 4 weeks

Secondary outcomes

  1. Tcpo2 at ulcer edge using Pulse Oximeter

    Time frame: 4 weeks

  2. Emg pre and at end (Sensory NCS (Sural nerve)

    Time frame: 4 weeks

Sponsors and collaborators

Lead sponsor

Al-Zaytoonah University of Jordan

Other

Registry information

Official study title

Hyperbaric Oxygen Therapy Combined With Polarized Light Therapy Effect on Neuropathic Foot Ulcer Regarding Transcutaneous Oxygen Saturation (TcpO2) and Healing Rate ( A Randomized Control Study)

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 21, 2025
Registry last updated
Aug 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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