Hyperbaric Oxygen Therapy and Insulin Resistance (HOTAIR2) - Effect of One HBO Session.

Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have recently shown that exposure to hyperbaric oxygen (HBO) leads to an increase insulin sensitivity in males ubjects and that this improvement can be measured in all men, not just those with diabetes. The aim of this study is to investigate the time course of this effect and explore the mechanisms involved. The investigators suspect that insulin sensitivity as measured by hyperinsulinaemic-euglycaemic clamp will be increased within the time-frame of one 2-hour hyperbaric oxygen exposure, and that the improvement will be measurable in females as well as males.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Obesity Body Weight Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Hyperinsulinism Hypoxia Inflammation Insulin Resistance Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory Type 2 Diabetes

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Overweight to obese (BMI 25-35 kg/m2)
Age >18 years (no specific upper age limit)
Fit to enter hyperbaric chamber as assessed by hyperbaric physician.

Exclusion criteria

Personal history of Diabetes
Personal history of major psychiatric disorders
UIse of prescribed or non-prescribed medications which may affect glucose homeostasis (e.g. steroids),
Uncontrolled asthma,
Current fever or upper respiratory infections
Individuals who regularly perform high intensity exercise (>2 week),
Pregnancy, lactation and women who are planning to become pregnant
Current intake of >140g alcohol/week,
Current smokers of cigarettes/cigars/marijuana,
Current inatke of any illicit substance,
Claustrophobia
has donated blood within past 3 months.

Treatment and study plan

Hyperbaric Oxygen Therapy

Procedure

Participants will undergo 2 treatments of hyperbaric oxygen. Each treatment consists of 90 minutes compression at 2 atmospheres of pressure, with 30 minutes decompression back to 1 atmosphere. During this time, patients will be treated with 100% oxygen delivered via a hood system.

Primary outcomes

Insulin sensitivity

Time frame: 2 hours

Secondary outcomes

Hypoxia and inflammatory markers

Time frame: 2 hours

Using immuno-histo chemistry (IHC), quantitative plymerase chain reaction (qPCR), Western blot

Sponsors and collaborators

Lead sponsor

University of Adelaide

Other

Registry information

Acronym: HOTAIR2

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Dec 12, 2013
Registry last updated: Dec 2, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed