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Completed

NCT Number: NCT06788015

Hydrogen-Infused Water for Endurance Performance, Body Hydration Biomarkers, and Health-Related Quality of Life

The study investigates the impact of 4-week hydrogen-infused water consumption on various health and performance outcomes. Conducted with healthy young adults, the trial assesses endurance performance, hydration biomarkers, and health-related quality of life. Participants are randomized into intervention and control groups, with outcomes measured over a specified period. The findings aim to elucidate whether hydrogen-infused water water provides significant benefits for physical performance, hydration status, and overall well-being compared to standard hydration methods.

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Key information

Conditions

Exercise Overtraining Fatigue Overtraining Syndrome Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

FSPE Applied BIoenergetics Lab

Novi Sad, Vojvodina, 21000, Serbia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18.0 - 29.9 years
  • Body mass index 18.5 - 24.9 kg/m2
  • Collegiate athletes with training experience >3 years
  • Weekly exercise > 5 hours
  • Given written informed consent

Exclusion criteria

  • Major chronic diseases or acute disorders
  • History of dietary supplement usage in the 4 weeks preceding the study initiation
  • Unwillingness to return for a follow-up
  • Participation in other clinical trials

Treatment and study plan

Hydrogen-infused water

Dietary Supplement

Water containing molecular hydrogen

Placebo

Dietary Supplement

Water containing no molecular hydrogen

Primary outcomes

  1. Time to exhaustion

    Time frame: Change from baseline time to exhaustion at 4 weeks

    Running time to exhaustion at treadmill

Secondary outcomes

  1. Total body water

    Time frame: Change from baseline total body water at 4 weeks

    Level of total body water

Other outcomes

  1. 36-Item Short Form Health Survey

    Time frame: Change from baseline 36-Item Short Form Health Survey total score at 4 weeks

    Short Form Health Survey total score, minimum and maximum possible score of between 0 and 100, with higher scores mean better outcome

Sponsors and collaborators

Lead sponsor

University of Novi Sad, Faculty of Sport and Physical Education

Other

Registry information

Official study title

The Effects of Hydrogen-Infused Water on Endurance Performance, Body Hydration Biomarkers, and Health-Related Quality of Life in Healthy Young Men and Women (HYDRO2EAU): A Randomized-Controlled Clinical Trial

Acronym: HYDRO2EAU

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jan 22, 2025
Registry last updated
Dec 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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