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OpenTrials
Completed

NCT Number: NCT02486419

Human Neck Brown Adipose Tissue mRNA Profile, a Seasonal Variation Study.

The primary objective in this study is to examine the seasonal variation in genetic markers in the deep neck adipose tissue in humans.

Human adipose tissue biopsies are taken from patients admitted for elective surgery in the neck. During the surgical procedure a subcutaneous adipose tissue biopsy is taken for reference.

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Key information

Conditions

Nonshivering Thermogenisis

Sex eligibility

All sexes

Study type

Observational

Primary location

Aarhus University Hospital

Aarhus, Central Jutland, 8000, Denmark

About this study

The knowledge of brown adipose tissue (BAT) is derived mainly from studies in rodents where cold is an important regulator of BAT development and function. Yet, little is known about the regulation of BAT in humans.

With this study the investigators aim to investigate the effects of seasonal changes in outdoor temperature on genetic markers of BAT in human deep neck adipose tissue.

Project participants are patients who are admitted to Aarhus University Hospital for elective neck surgery. Operations are primarily due to suspected malignancy in the thyroid gland or hyperparathyroidism.No additional surgery is necessary to obtain the biopsies.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • written concent

Exclusion criteria

-

Treatment and study plan

Outdoor weather

Other

Seasonal changes in temperature

Primary outcomes

  1. Differences in gene expression in BAT associated genes (PGC1a, UCP1, CIDEA, PRDM16)

    Time frame: 1 day (The biopsies will be taken as a "point in time" value. Differences between seasons will be assesed. And so will correlations between genes at one point in time.)

    biopsies will be grouped depending on outdoor temperature, differences in subcutaneous- and deep neck values,

Sponsors and collaborators

Lead sponsor

Aarhus University Hospital

Other

Collaborators

  • Novo Nordisk A/S

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Jul 1, 2015
Registry last updated
Aug 3, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.