Human Immunome Program

Inclusion criteria

• Healthy male and female volunteers between the ages of 18 - 49 years of age at the time of first enrollment.
• Ability to comply: Participant willing and able to comply with the requirements of the protocol.
• Consent: Participants who have given informed consent for participation in the study

Exclusion criteria

Reason for exclusion throughout the entire study period:

• History of severe anemia requiring blood transfusion or current Hemoglobin < 10g/dL.
• Currently pregnant or pregnancy within 6 months.
• Current participation in another study resulting in blood collection which exceeds 550 ml in an 8 week period or occurs more frequently than 2 times per week.
• Temperature >101.4F
• Any condition which, in the opinion of the investigator, might interfere with study objectives.
• Any reason which, in the opinion of the investigator, adds additional risk to the patient.

Reason for exclusion in year 0 but not in year 1-9:

• History of known HIV infection or treatment.
• Immunosuppressive disease or use of systemic immunosuppressive therapy using drugs or cytotoxic agents including prednisone (IV, oral or inhaled) less than 6 months ago.
• History of diabetes mellitus -or a glucose (on CMP) ≥200 mg/dL.
• History of cancer including skin cancer.
• History of autoimmune disorders including but not limited to: Ulcerative colitis, Crohn's, Inflammatory Bowel Disease, Rheumatoid Arthritis, Scleroderma, Systemic lupus Erythematosus, Mixed Connective Tissue Disease, Graves, Autoimmune Thyroiditis, Hashimoto's Thyroiditis, Psoriasis, Multiple Sclerosis, Guillain-Barre Syndrome, Chronic Inflammatory demyelinating polyneuropathy, Myasthenia Gravis, Vasculitis, Alopecia areata, autoimmune hemolytic anemia, autoimmune hepatitis, dermatomyositis, idiopathic thrombocytopenic purpura, pemphigus, pernicious anemia, polyarteritis nodosa, polymyositis, Sjogren's Syndrome, Wegener's
• Severe obesity = (BMI >40 kg/m2).