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OpenTrials
Completed

NCT Number: NCT00870025

Human Chorionic Gonadotropin (hCG) Priming Prior to Controlled Ovarian Hyperstimulation (COH) in Poor Responder In Vitro Fertilization (IVF) Patients

There is a decline in androgen concentration with ovarian aging. Also, ovarian response to COH in IVF cycles diminishes with ovarian aging. Recent evidence suggest that testosterone or DHEA may improve ovarian response in poor prognosis patients by increasing intraovarian androgen concentration. A physiological way to induce androgen synthesis within the ovary is to stimulate theca cells androgen production by hCG stimulation. By doing this in the previous cycle we might expect a better response to COH.

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Key information

Conditions

Ovarian Response

Age range

18 year–41 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

IVI-Madrid

Madrid, 28023, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • previous IVF cycle with 5 or less mature follicles or 5 or less oocyte retrieved

Exclusion criteria

  • 42 years or older
  • BMI <18 or >30

Treatment and study plan

human chorionic gonadotropin

Biological

200 IU, sc, every 5 days, 4 doses

Placebo

Biological

diluent, every 5 days, s.c., 4 doses

Primary outcomes

  1. pregnancy rate

    Time frame: 2 weeks after intervention

Secondary outcomes

  1. number of oocytes retrieved

    Time frame: 2 weeks after intervention

Sponsors and collaborators

Lead sponsor

IVI Madrid

Other

Registry information

Official study title

hCG Priming Prior to COH in Poor Responder IVF Patients

Acronym: APPE

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Mar 26, 2009
Registry last updated
Apr 22, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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