Basaksehir Cam Sakura City Hospital
Istanbul, Turkey (Türkiye)
NCT Number: NCT05814081
Introduction: Intraoperative Mechanical Ventilation practices can lead to ventilator-associated lung injury (VILI) and postoperative pulmonary complications in healthy lungs. Mechanical Power has been developed as a new concept in reducing the risk of postoperative pulmonary complications as it takes into account all respiratory mechanics that cause VILI formation. Volume control mode is at the forefront in the old anesthesia devices used in the operating room, and today, together with technology, there are anesthesia devices with many modes and features, as in intensive care units. This causes confusion in the use of mechanical ventilators. In this study, volume and pressure control ventilation modes were compared in terms of respiratory mechanics (including mechanical power) in patients operated in the supine and prone positions.
Aim of study: It has been compared the effects on postoperative pulmonary complications (PPH) in terms of VILI risk by calculating mechanical power from advanced respiratory mechanics of patients ventilated in pressure and volume control modes, which are frequently used in operating room applications.
Conclusion: There was no statistically significant difference between the groups in terms of demographic data, ariscat score, and ariscat risk group values. The supine and prone mechanical power (MPrs) values of the volume control group were statistically significantly lower than the pressure control group. P values were calculated as 0.012 and 0.001, respectively.
Results: Supine and prone MPrs values of the volume control group were calculated significantly lower than the pressure control group. Pressure-controlled intraoperative mechanical ventilation is considered to be disadvantageous in terms of the risk of VILI in the supine and prone position in terms of the current mechanical power concept.
Looking for future studies?
Notify Me18 year–70 year
All sexes
Observational
Istanbul, Turkey (Türkiye)
Although mechanical ventilation is a life-saving intervention, it can lead to ventilator-induced lung injury (VILI). VILI is the damage caused by positive pressure ventilation that starts with the use of mechanical ventilators. There are many factors that cause VILI such as tidal volume, drive pressure, flow, respiratory rate, and PEEP. Mechanical power, which collects these different variables in a single parameter, offers us new possibilities in predicting VILI at the bedside. The mechanical power being above a certain threshold causes damage ranging from pulmonary parenchymal rupture to severe inflammation and edema. Also, higher mechanical power values are associated with higher mortality. The protective ventilation strategy in intensive care units is also applied in operating rooms (OR) to minimize the risk of postoperative pulmonary complications due to VILI. While the volume control mode was at the forefront in the old anesthesia devices used in the OR, today there are anesthesia devices with many modes and features, as in intensive care units. This causes confusion in the use of mechanical ventilators in the perioperative period. Therefore, in this study, the investigators compared the perioperative mechanical power values in prone and supine positions, and postoperative pulmonary complications of two ventilation modes (volume control-pressure control ventilation). Thus, the investigators aimed to find out which ventilation mode would be advantageous in the perioperative period.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Positioning and ventilation mode adjustments were made to the patients.
Time frame: During surgery (2 hours to 4 hours)
Mechanical power values calculated during surgery were compared.
Time frame: Postoperative period (up to 10 days)
Postoperative pulmonary complications were observed.
Time frame: During surgery (2 hours to 4 hours)
PEEP(mmHg) value measured during surgery were compared.
Time frame: During surgery (2 hours to 4 hours)
Tidal volume(ml) value measured during surgery were compared.
Time frame: During surgery (2 hours to 4 hours)
Peak pressure(mmHg) value measured during surgery were compared.
Time frame: During surgery (2 hours to 4 hours)
Plato pressure(mmHg) value measured during surgery were compared.
Time frame: During surgery (2 hours to 4 hours)
Driving pressure(mmHg) value measured during surgery were compared.
Time frame: During surgery (2 hours to 4 hours)
Inspiratory time(second) value measured during surgery were compared.
Başakşehir Çam & Sakura City Hospital
Other Gov
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT03165760
Lung Diseases, Lung Injury
View Trial DetailsNCT07349719
Bone Diseases, Hernia
Ankara, Turkey (Türkiye)
View Trial DetailsNCT02025075
Intraoperative Complications, Laparoscopy
Boston, Massachusetts, United States
View Trial DetailsNCT05991258
Acute Respiratory Failure, Lung Diseases
Padua, Italy
View Trial Details