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OpenTrials
Completed

NCT Number: NCT02917252

How Orally Consumed 3-hydroxybuturate Alters Metabolism

This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.

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Key information

Conditions

Acute Ketosis

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Aarhus University Hospital

Aarhus, 8000, Denmark

About this study

Subject participate for two separate days; i) intervention, ii) placebo. Intervention: subjects drink ketone body solution. Tracer kinetics on glucose and lipid metabolism is applied. Muscle tissue and adipose tissue biopsies are taken.

Placebo: subjects drink saline. Same sampling as on intervention day.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI 20-30

Exclusion criteria

  • Smoking
  • alcohol or drug abuse
  • Critically ill

Treatment and study plan

3-hydroxybuturate

Other

Drink of ketone bodies

Placebo

Other

Drink of saline

Primary outcomes

  1. 3-hydroxybuturate

    Time frame: 0-270 minutes

    blood level of 3-hydroxybuturate

Secondary outcomes

  1. Glucose

    Time frame: 0-270 minutes

    Glucose tracer kinetics, endogenous glucose production, muscle biopsy

  2. lipid metabolism

    Time frame: 0-270 minutes

    Palmitate tracer kinetics, free fatty acid accumulation, adipose tissue biopsies

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

Ketone Bodies Ingested Orally Alter Metabolism for Glucose, Lipid, and Protein

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Sep 28, 2016
Registry last updated
Apr 10, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.