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OpenTrials
Completed

NCT Number: NCT00747383

How Improvement in Control of Diabetes Influences the Production of a Hormone Produced in the Gut Which Improves the Release and Action of Insulin.

The study is aimed at Type 2 Diabetics who are taking Metformin, but whose Diabetes remains poorly controlled. There are two additional medications already in use, Glimepiride and Sitagliptin will be compared to assess levels of improvement in Diabetes control.

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Key information

Conditions

Type 2 Diabetes Mellitus Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Royal Bournemouth Hospital

Bournemouth, Dorset, BH7 7DW, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diabetes Mellitus
  • Currently on Metformin but poor glycaemic control,

Exclusion criteria

  • Under 18 years of age

Treatment and study plan

Glimepiride

Drug

3mg oral tablet.

Other names: Amaryl.

Sitagliptin

Drug

100mg oral tablet.

Other names: Januvia.

Primary outcomes

  1. Comparison of GLP-1 response at baseline and after 3 months treatment of both groups.

    Time frame: 2 years

Sponsors and collaborators

Lead sponsor

The Royal Bournemouth Hospital

Other

Collaborators

  • Merck Sharp & Dohme LLC

Registry information

Official study title

Influence of Improving Glycaemic Control on Glucagon-Like-Peptide-1 Response to an Oral Glucose Load. Comparison of Sulphonylurea With DPP-4 Inhibition.

Acronym: MSD-GLP1

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Sep 5, 2008
Registry last updated
Dec 5, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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