How Can Prefabricated Membranes Load Ascorbic Acid Can Curtail Gingival Recession?

Periodontal diseases are a prevalent issue, often leading to gingival recession, where the gingival margin recedes, exposing the tooth root and causing various problems. Gingival recession can be managed through both non-surgical and surgical interventions The non-surgical approach often involves plaque control and addressing any underlying inflammatory conditions. However, in cases of advanced recession, surgical treatment may be necessary Several treatment techniques have been proposed, which can be divided into pedicle and free grafts. The latter can also be classified as free gingival grafts (FGG) or as connective tissue grafts (CTG). Other treatment options include soft tissue substitutes or regenerative therapies Harvesting graft from the palate has several problems, such as pain, inflammation, bleeding, flap necrosis, and infection at the donor site. For this reason, we need a substitute for soft tissue graft harvesting Carbopol polymers, also known as carbomers, are widely utilized in pharmaceutical formulations for their excellent mucoadhesive properties. This high molecular weight, cross-linked acrylic acid polymers are particularly effective in enhancing the adhesion of formulations to mucosal surfaces, thereby improving drug delivery and bioavailability

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Key information

Conditions

Gingival Recession, Localized Gingival Diseases Gingival Recession Mouth Diseases Periodontal Atrophy Periodontal Diseases Recession, Gingival Stomatognathic Diseases

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Gingival recession is a common finding in daily clinical practice. Several issues may be associated with the apical shift of the gingival margin such as dentine hypersensitivity, root caries, non-carious cervical lesions (NCCLs), and compromised aesthetics. The first step in an effective management and prevention program is to identify susceptibility factors and modifiable conditions associated with gingival recession. Non-surgical treatment options for gingival recession defects include establishing optimal plaque control, removing overhanging subgingival restorations, behavior change interventions, and using desensitizing agents. In cases where a surgical approach is indicated, coronally advanced flap and tunneling procedures combined with a connective tissue graft are considered the most predictable treatment options for single and multiple recession defects. If there is a contraindication for harvesting a connective tissue graft from the palate or the patient wants to avoid a donor site surgery, adjunctive use of acellular dermal matrices, collagen matrices, and/or enamel matrix derivatives can be a valuable treatment alternative. For gingival recession defects associated with NCCLs a combined restorative-surgical approach can provide favourable clinical outcomes. If a patient refuses a surgical intervention or there are other contraindications for an invasive approach, gingival conditions should be maintained with preventive measures. This paper gives a concise review of when and how to treat gingival recession defects.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients of both genders with ages more than 18 years.
At least two adjacent teeth in maxillary or mandibular anterior sextant with Cairo classification (RT1 or RT 2) labial GR defect.
Good general health with no contraindications for periodontal surgery (American Society of Anesthesiologists I).
Non-smoker patients.

Exclusion criteria

Pregnant and lactating women.
Teeth exhibiting pathologic mobility.
Mal alignment teeth.
Patients under active orthodontic therapy.
Periodontal therapy during the last 6 months.
Patients received antibiotics or non-steroidal anti-inflammatory drugs six months before the beginning of the study.

Treatment and study plan

ascorbic acid

Drug

Ascorbic acid induce gingival healing

Primary outcomes

Gingival recession height

Time frame: baseline, 3months and 6 months

The distance from the cementoenamel junction to the gingival margin

Study contacts

Contact information is provided by the study sponsor or research team.

shaimaa Hamdy, lecturer of Periodontology

CONTACT

[email protected]

+201030576405 ext. +201555035523

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Official study title

How Can Prefabricated Membrane-loaded Ascorbic Acid Curtail the Gingival Recession?

Acronym: recession

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Apr 20, 2025
Registry last updated: Apr 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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