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Completed

NCT Number: NCT06806943

How Avatar Can Enhance Autobiographical Memory of Patients With Substance Use Disorder

The goal of this study is to investigate whether the use of artificial intelligence platforms can promote the retrieval of specific positive autobiographical memories.

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Key information

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Le.L.A.T. Lega Lotta Aids E Tossicodipendenza

Messina, 98124, Italy

About this study

The decision to focus on the retrieval of positive autobiographical memories was made for ethical reasons and is not tied to any specific research hypothesis. Specifically, the study aims to assess whether artificial intelligence facilitates the sharing of personal experiences and reflection on autobiographical memories related to substance use disorders, taking into account the potential influence of individual characteristics such as recent mood state, and overall memory functioning.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of substance use disorder
  • Admitted to the drug rehabilitation center for at least 3 months
  • Aged 18 years or older

Exclusion criteria

  • Previous neurological pathologies
  • Previous cognitive deficits

Treatment and study plan

avatar-based interactions

Device

SUD patients were investigated using the Autobiographical Memory Test in two conditions: face-to-face and avatar-based interactions. Patients had to recall 6 neutral cue words and 6 substance-related cue words for each condition.

Primary outcomes

  1. Change in Specific Autobiographical Memory Recall

    Time frame: During the intervention sessions for both conditions (avatar-based and face-to-face). This outcome directly reflects the study's objective by quantifying the change of AM recall through avatar-based interventions.

    The primary outcome measure is the difference in the number of specific autobiographical memories recalled between the avatar-based interaction condition and the face-to-face condition, as assessed by the Autobiographical Memory Test (AMT). Specificity of recalled memories are scored using standardized criteria. This measure evaluates the effectiveness of avatar-based interventions in changing AM recall in patients with substance use disorder (SUD).

Secondary outcomes

  1. Latency of Autobiographical Memory Recall

    Time frame: During the intervention sessions for both conditions (avatar-based and face-to-face).

    The secondary outcome measure is the comparison of latency times (time taken to recall a memory) between the avatar-based interaction condition and the face-to-face condition, as recorded during the Autobiographical Memory Test (AMT). This measure evaluates whether the use of avatar-based interventions change the speed of autobiographical memory recall in patients with substance use disorder (SUD).

  2. Pleasantness of Autobiographical Memories Recalled

    Time frame: During the intervention sessions for both conditions (avatar-based and face-to-face).

    The secondary outcome measure is the comparison of pleasantness ratings of autobiographical memories recalled between the avatar-based interaction condition and the face-to-face condition. Pleasantness is assessed during the Autobiographical Memory Test (AMT). This measure evaluates whether avatar-based interventions change the emotional valence of the memories retrieved by patients with substance use disorder (SUD).

  3. Change in Age Memory Recall

    Time frame: During the intervention sessions for both conditions (avatar-based and face-to-face).

    The secondary outcome measure is the change in age memory recall, defined as the participants' ability to identify the age at which autobiographical memories occurred, comparing the avatar-based interaction condition to the face-to-face condition. Age memory is assessed during the Autobiographical Memory Test (AMT) for each recalled memory. This measure evaluates whether avatar-based interventions change temporal specificity in autobiographical memory recall among patients with substance use disorder (SUD).

Sponsors and collaborators

Lead sponsor

Le.L.A.T. Lega Lotta Aids E Tossicodipendenza

Other

Collaborators

  • Catholic University of the Sacred Heart

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Feb 4, 2025
Registry last updated
Feb 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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