Host-microbiota Interactions in Auto-inflammatory Diseases

Patients will receive oral and written information about the research during a routine consultation.

A 10mL urine tube will be collected for research. A stool collection kit including a self-questionnaire to be filled out on the day of the stool collection will be given to all included patients to be collected on site or at home within three months after inclusion and to be returned to the laboratory by mail using a pre-stamped envelope provided at the time of inclusion and a self-questionnaire to be filled out on the day of the stool collection Blood and urine samples will be brought by an accredited carrier to the laboratory "Microbiota, Intestine and Inflammation"; UMRS-938 Sorbonne University, Hôpital Saint-Antoine where they will be analyzed. Stool samples will be sent by mail for stool samples.

If blood sampling is planned as part of routine care, 3 additional tubes (15mL, one dry tube of 5mL, 2 EDTA tubes of 5mL each) of peripheral blood will be collected.

Inclusion criteria

• Patients with autoinflammatory diseases aged >12 years and followed in the CEREMAIA internal medicine department present for consultation or day hospital for a routine care visit.
• FMF defined by the Eurofever/PRINTO criteria
• or CAPS définie by the Eurofever/PRINTO criteria
• or MKD defined by the Eurofever/PRINTO criteria
• or - DADA2 defined by the presence of two mutations in the ADA2 gene with pathogenicity of at least ≥ 3
• or - HA20 defined by the presence of one TNFAIP3 mutation with pathogenicity of at least ≥ 3
• or - JAAD defined by the presence of one JAK1 mutation with pathogenicity of at least ≥ 3
• or Juvenile polyarthritis defined by the presence of one LACC1 mutation with pathogenicity of at least ≥ 3
• or - Unclassified AMI defined by:

• Fever +/- systemic symptoms Recurrent
• Biological inflammation (CRP>20mg/l) in crisis or permanent
• Absence of pathogenic mutation highlighted by current next-generation sequencing techniques in known autoinflammatory disease genes
• Collection of non-opposition to participation in research and specific consent for the biological collection of the patient or their legal representative in the case of a minor patient
• Lack of legal protection
• Patients benefiting from a social security scheme

Exclusion criteria

• Antibiotic therapy within 3 months prior to inclusion. If antibiotic therapy was initiated between inclusion and stool collection (data collected on the self-administered questionnaire accompanying the stool collection), the analysis data performed prior to antibiotic therapy will be retained, and the stool will not be analyzed.
• Current infection on the day of inclusion
• No social security
• Refusal to participate