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Completed

NCT Number: NCT06523075

Host Dysregulation-Driven Sepsis Prediction Model

The aim of this study is to identify risk factors associated with sepsis and to construct a predictive model for sepsis. This will provide an objective theoretical and empirical foundation for the diagnosis, assessment, and management of sepsis in our country.The primary questions addressed are:

What are the risk factors for the development of sepsis? How do we improve the prognosis of sepsis?

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Key information

Conditions

Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,, Wenzhou, Zhejiang, China

Loading trial locations.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with Infection or Suspected Infection

Exclusion criteria

  • Patients with Autoimmune Diseases
  • Pregnant Women
  • Patients with Advanced-Stage Cancer and Systemic Metastasis

Treatment and study plan

Tumor Necrosis Factor

Other

This study is a retrospective observational study, with Tumor Necrosis Factor being one of the exposure factors under investigation.

Interleukin-1β

Other

This study is a retrospective observational study, with Interleukin-1β being one of the exposure factors under investigation.

Interleukin-12

Other

This study is a retrospective observational study, with Interleukin-12 being one of the exposure factors under investigation.

Interleukin-18

Other

This study is a retrospective observational study, with Interleukin-18 being one of the exposure factors under investigation.

Complement C3

Other

This study is a retrospective observational study, with Complement C3 being one of the exposure factors under investigation.

Complement C5

Other

This study is a retrospective observational study, with Complement C5 being one of the exposure factors under investigation.

Primary outcomes

  1. Sepsis

    Time frame: 3 months

    A rapid increase of 2 or more points points in the Sequential Organ Failure Assessment (SOFA) score after patient infection.SOFA score, which ranges from a minimum of 2 to a maximum of 15, indicates a worse outcome with higher scores.

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital of Wenzhou Medical University

Other

Registry information

Official study title

Construction and Validation of a Sepsis Prediction Model Based on Dysregulation of Host Response

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 26, 2024
Registry last updated
Oct 31, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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