Hormone Dynamics and Bone Mineral Density in Anorexia Nervosa v. Hypothalamic Amenorrhea

The purpose of this study is to determine whether the hormone dynamics in women with anorexia nervosa and hypothalamic amenorrhea is related to bone loss in those populations.

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Key information

Conditions

Anorexia Nervosa Amenorrhea Behavior Behavioral Symptoms Body Weight Bone Diseases Bone Diseases, Metabolic Depression Feeding and Eating Disorders Hypothalamic Amenorrhea Menstruation Disturbances Mental Disorders Metabolic Diseases Motor Activity Musculoskeletal Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Osteoporosis Overnutrition Overweight Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Amenorrhea for at least three months (unless participating as healthy control)
Normal TSH or free thyroxine (free T4).

Exclusion criteria

A condition known to affect bone metabolism, including Cushing's syndrome or renal failure, with the exception of bone fracture.
Any medication known to affect bone metabolism within 3 months of the study, including estrogen and progestins. Patients receiving depot medroxyprogesterone (Depo-Provera) will be excluded from participating for 6 months after their last injection.
Pregnant and/or breastfeeding.
Diabetes mellitus.
Active substance abuse, including alcohol.

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Collaborators

Bioenvision
National Institutes of Health (NIH)

Registry information

Important dates

Study start: 2006
Primary completion: 2009
Study completion: 2009
First posted: Nov 9, 2007
Registry last updated: Sep 2, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed