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NCT Number: NCT06316557

HOPE From the Cerebellum: TMS-Induced Cognitive Recovery After Stroke

The objective of this clinical trial is to investigate the effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) in the cerebellum for individuals with post-stroke cognitive impairment. Participants will undergo rTMS in the cerebellar hemisphere opposite the lesion site, once daily for a total of five days.

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Key information

Conditions

Post-stroke Cognitive Impairment Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemic Stroke Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Beijing Tiantan hospital

Beijing, 100070, China

Location status: Recruiting

Location contact

Weili Jia

CONTACT

[email protected]

+86 13120207987

Zixiao Li, Dr.

PRINCIPAL_INVESTIGATOR

About this study

The primary objective of this clinical trial is to investigate the effectiveness and safety of intermittent theta burst stimulation ( iTBS) in the cerebellum for individuals with post-stroke cognitive impairment. The trial aims to answer two main questions: (1) What is the effectiveness of iTBS in improving post-stroke cognitive impairment? (2) Is iTBS in the cerebellum safe for individuals with post-stroke cognitive impairment? Participants will undergo iTBS in the cerebellar opposite the lesion site, twice daily for five days. The control group will receive sham rTMS with the same parameters and positions.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Key inclusion criteria:

(1)ischemic stroke, with an initial incident occurring within 2 weeks;(2)MoCA<26;

Key exclusion criteria:

(1)Cerebral hemorrhage or subarachnoid hemorrhage;(2)A pre-existing history of epilepsy;

Treatment and study plan

iTBS group

Device

iTBS on the contralesional cerebellum, twice a day for seven days

Control group

Device

shame stimulation on the contralesional cerebellum, twice a day for seven days

Primary outcomes

  1. The efficacy of improving cognitive function of post-stroke cognitive impairment

    Time frame: 3 months follow-up after treatment

    The change of MoCA between baseline and 3 months follow-up

Secondary outcomes

  1. The safety of improving cognitive function of post-stroke cognitive impairment

    Time frame: day1-day7

    Incidence of epilepsy during treatment

Study contacts

Contact information is provided by the study sponsor or research team.

Weili Jia, Dr.

CONTACT

[email protected]

+86 13120207987

Sponsors and collaborators

Lead sponsor

Zi-Xiao Li

Other

Registry information

Acronym: HOPE

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Mar 18, 2024
Registry last updated
Jul 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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