Skip to main content
OpenTrials
Completed

NCT Number: NCT06170073

Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality

Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Sleep Disturbance Aging Brain Disease Brain Diseases Central Nervous System Diseases Cognition Disorders Cognitive Decline Cognitive Dysfunction Mental Disorders Nervous System Diseases Neurocognitive Disorders Parasomnias Sleep Wake Disorders

Age range

55 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Chinese University of Hong Kong

Hong Kong, Tai Po District, 100000

About this study

Objectives: This study aims to investigate the cognitive changes in older adults with sleep disturbances, examine the neuroimaging contributors to poor sleep quality and cognitive deficits.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chinese old adults are the ones who are over 60 years of chronological age.
  • Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score >5.

Exclusion criteria

  • History of bipolar disorders or psychosis.
  • History of major neurological deficits, including stroke, transient ischemic attack or brain tumor.
  • Unable to participant magnetic resonance imaging (MRI) scanning.

Treatment and study plan

Primary outcomes

  1. Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI)

    Time frame: Baseline

    Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item self-reported questionnaire

  2. Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)

    Time frame: Baseline

    The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention.

  3. Complex attention will be measured by the Attention Network Test (ANT)

    Time frame: Baseline

    The ANT paradigm, as a computerized test, was used and performed by E-Prime 3.0.

Secondary outcomes

  1. Memory and learning will be measured by the Word list learning test (WLLT)

    Time frame: Baseline

    Word list learning test (WLLT), consisting of fifteen semantically non-associated words that is presented consecutively over three free trials of immediate recall, a 20-min delayed recall and followed by yes/no recognition.

  2. Executive functions will be measured by the category verbal fluency test (CVFT)

    Time frame: Baseline

    On each trial of CVFT, the participants will be asked to overtly generate words in the animal category, fruit category and vegetable category as many as possible within 60 seconds

  3. The levels of Aβ40 and Aβ42 will be measured by saliva analysis

    Time frame: Baseline

    saliva samples will be collected at a consistent time of day to avoid circadian effects and will be kept on ice during the collection.

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Collaborators

  • The University of Hong Kong

Registry information

Official study title

Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): an Observational Study on Brain Health and Sleep Quality in Community-dwelling Older Adults

Acronym: HK-ASAP

Important dates

Study start
2023
Primary completion
2024
Study completion
2025
First posted
Dec 14, 2023
Registry last updated
Jan 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.