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NCT Number: NCT07401069

Homemade Herbal Mouthwash in Gingivitis. A Randomized Clinical Trial.

Gingivitis is a very common oral disease that may progress to the more destructive periodontitis if not treated. As oral plaque is a key player in gingivitis, plaque control by professional scaling and oral hygiene measures represents the main line of treatment.

Among the oral hygiene measures, using chlorhexidine mouthwash is considered the gold standard in mouthwashes. However, due to its side effects, a safer and more acceptable mouthwash is needed. Therefore, this study proposes mouthwashes made of infusion of natural herbs as an alternative.

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Key information

Conditions

Gingivitis Gingival Diseases Infections Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Plaque-induced gingivitis.

Exclusion criteria

  • Medically compromised.
  • History of medications.
  • Pregnant females.
  • Periapical involvement in teeth.
  • History of periodontal surgery.
  • If gingivitis was due to local factor.

Treatment and study plan

Chlorhexidine 0,12%

Drug

chlorhexidine 0.12% mouthwash twice daily for 7 days

herbal Mouthwash

Drug

Mouthwash made at home by boiling herbs in water and then saving the solution in a tightly closed container for daily use for 7 days

Primary outcomes

  1. plaque index (O'Leary et al., 1972)

    Time frame: 7 days

    Plaque accumulation is tested on teeth with a probe. Number of sites having plaque accumulation will be divided by the total number of dental sites to get percentage of plaque accumulation.

Secondary outcomes

  1. Bleeding on probing

    Time frame: 7 days

    Bleeding on probing is tested on teeth with a periodontal probe. Number of sites showing bleeding will be divided by the total number of dental sites to get percentage of bleeding on probing.

  2. Changes in clinical signs of inflammation (Armitage, 2004)

    Time frame: 7 days

    Results will be in the form of (Yes/No); indicating if the gingival clinical condition (color and contour) was improved or not

  3. Bleeding on brushing

    Time frame: 7 days

    Evaluation of extent of daily bleeding on brushing using VAS.

  4. Patient's acceptance of the mouthwash

    Time frame: 7 days

    questionnaire

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

The Effect of Homemade Herbal Mouthwash Versus Chlorhexidine on Plaque Accumulation in Gingivitis. A Randomized Clinical Trial.

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 10, 2026
Registry last updated
Feb 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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