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NCT Number: NCT07635329

Home-based Vision Rehabilitation Guided by Brain Imaging

The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.

Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.

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Key information

Conditions

Visual Field Defect Blindness Blindness, Cortical Brain Diseases Brain Injuries Brain Injuries, Traumatic Brain Neoplasms Brain Tumor Cardiovascular Diseases Central Nervous System Diseases Central Nervous System Neoplasms Cerebrovascular Disorders Cortical Blindness Craniocerebral Trauma Eye Diseases Hemianopia Homonymous Hemianopsia Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms Neurologic Manifestations Pathological Conditions, Signs and Symptoms Quadrantanopia Sensation Disorders Signs and Symptoms Stroke Trauma, Nervous System Traumatic Brain Injury Vascular Diseases Vision Disorders Visual Field Defect, Peripheral Visual Field Loss Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Georgetown University Medical Center

Washington D.C., District of Columbia, 20057, United States

Location status: Recruiting

Location contact

Tina Liu, PhD

CONTACT

[email protected]

202-784-9949

Tina Liu, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • At least 18 years of age.
  • Capable of providing informed consent and complying with study procedures.
  • Unilateral or bilateral focal brain damage causing visual field loss.
  • At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.
  • Eligible for MRI based on standard safety screening.

Exclusion criteria

  • Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.
  • Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.
  • Ocular disease or disorder.

Treatment and study plan

High-level perceptual learning-based training

Behavioral

Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing

Low-level perceptual learning-based training

Behavioral

behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing

Primary outcomes

  1. Change in high-level perceptual discrimination performance

    Time frame: Week 2-4 or Week 7-9 of the study (depending on the order)

    Change in performance on an online computerized high-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.

  2. Change in low-level perceptual discrimination performance

    Time frame: Week 2-4 or Week 7-9 of the study (depending on the order)

    Change in performance on an online computerized low-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.

Study contacts

Contact information is provided by the study sponsor or research team.

Tina Liu, PhD

CONTACT

[email protected]

2027849920

Sponsors and collaborators

Lead sponsor

Georgetown University

Other

Collaborators

  • American Heart Association

Registry information

Official study title

Behavioral Rehabilitation Through Image-Guided Home-based Training

Acronym: BRIGHT

Important dates

Study start
2026
Primary completion
2030
Study completion
2030
First posted
Jun 9, 2026
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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