HLA-Haploidentical Peripheral Blood Stem Cell Transplantation With Post-transplant Cyclophosphamide and Bortezomib

Inclusion criteria

• 18-65 years old patient lacking a matched related donor or unrelated donor but have a related haploidentical donor (</= 7/8 allele match at the A, B, C, DR loci with a minimum match of 5/10 is required) is identified
• Candidate for stem cell transplant in a malignant hematological condition
• Karnofsky Performance Scale 0-1
• Available donor able to undergo a Peripheral blood stem cells collection
• Bilirubin </= 1.5 mg/dl , aspartate aminotransferase (AST) or alanine aminotransferase (ALT) </= 200 IU/ml for adults.
• Serum creatinine clearance >/=60 ml/min (calculated with Cockroft-Gault formula)
• Diffusing capacity for carbon monoxide (DLCO) >/= 45% predicted corrected for hemoglobin.
• Left ventricle ejection fraction > 40%.
• Patient or patient's legal representative, parent(s) or guardian should provide written informed consent.

Exclusion criteria

• Adult who has a suitable related or unrelated donor or cord units available for transplant. Suitable donors include 8/8 (HLA-A,B,C and DR, with all loci high-resolution typing) or 7/8 related or unrelated donor available within 42 days of search initiation
• HIV positive; active hepatitis B or C
• Patients with active uncontrolled infections.
• Liver cirrhosis
• Uncontrolled central nervous system involvement by tumor cells
• Positive Beta Human chorionic gonadotropin (HCG) test in a woman with child bearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization.
• Inability to comply with medical therapy or follow-up