HLA Antibodies in Systemic Lupus Erythematosus

Patients suffering from autoimmune diseases show false-positive results when anti-HLA antibodies are identified. This false positivity makes it difficult to obtain an organ transplant based on immunological compatibility (absence of anti-HLA antibodies directed against graft antigens). The objectives of this project are to study the prevalence of these false positivities in a population of lupus patients, and to evaluate biological tests that can negate these false positivities.

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Key information

Conditions

HLA Antibodies Autoimmune Diseases Connective Tissue Diseases Immune System Diseases Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases Systemic Lupus Erythematosus

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU Amiens

Amiens, 80054, France

Location status: Recruiting

Location contact

Nicolas Guillaume, Pr

CONTACT

[email protected]

33+322087046

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients Adults
Followed in the internal medicine department of Amiens University Hospital - With systemic lupus erythematosus
Without HLA immunization risk factors (no history of pregnancy, transfusions or transplants)
With sera stored in the biobank

Exclusion criteria

minor Patients
Opposing the re-use of their personal data for research purposes

Treatment and study plan

Primary outcomes

prevalence of unexplained antibody positivity

Time frame: 6 months

prevalence of unexplained antibody positivity

Study contacts

Contact information is provided by the study sponsor or research team.

Nicolas GUILLAUME, Pr

CONTACT

[email protected]

33+322087046

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: LEDHLA

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2027
First posted: Apr 10, 2025
Registry last updated: Jan 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Not Yet Recruiting