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Completed

NCT Number: NCT03158844

HIV Care Cascade and Linkage to Antiretroviral Therapy Among Hospitalized Adults in Lusaka, Zambia

The population of inpatients is large in Zambia; however, because of poor linkages between hospitals and community HIV care, there are few data to analyze their engagement in HIV care before and after hospitalization. The goal of the study is to learn more about Zambian adults who are HIV-infected and get hospitalized. The purpose of this study is to gather formative, preliminary data, to be used in future grant applications to improve linkage and engagement in HIV care in Zambia.

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Key information

Conditions

HIV Acquired Immunodeficiency Syndrome Blood-Borne Infections Communicable Diseases Genital Diseases HIV Infections Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Slow Virus Diseases Urogenital Diseases Virus Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Teaching Hospital

Lusaka, Zambia

About this study

The main objective of this study is to generate preliminary data on the outcomes of Zambian HIV-infected individuals after discharge from University Teaching Hospital (UTH) Internal Medicine wards which can inform development of a linkage intervention. Our central hypothesis is that in Sub-Saharan African settings like Zambia hospitalizations among HIV-infected individuals are driven by suboptimal linkage and initiation of ART following HIV diagnosis. Specific Aims: (a) Characterize the distribution of hospitalized 300 HIV-infected adults across the HIV care continuum. (b) Identify structural, psychosocial, clinic, and medical factors that predict suboptimal linkage to care and ART initiation after 90 days of hospital discharge among HIV-infected Zambians.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years or older
  • HIV-infected as documented in the UTH file
  • Admitted to Internal Medicine Ward at UTH

Exclusion criteria

  • Unable to provide informed consent
  • Not planning to remain in Lusaka province for 3 months after discharge

Treatment and study plan

Standard of care

Other

Routine standard of care per Ministry of Health protocol, including blood draws and examinations.

Primary outcomes

  1. Undetectable HIV viral load at 90 days post-discharge

    Time frame: 90 days after hospital discharge

    Numerator is number with HIV RNA <1000 c/mL tested at 90 days after hospital discharge; denominator is the # enrolled

Secondary outcomes

  1. Proportion of HIV-infected inpatients who are on ART upon admission

    Time frame: Baseline

    Numerator is number who report taking ART up to the time of admission; denominator is the # enrolled

  2. Mortality rate

    Time frame: 90 days after hospital discharge

    Mortality from time of enrollment to 90 days after discharge

  3. ART initiation

    Time frame: Baseline and 90 days after hospital discharge

    Proportion not on ART upon admission to hospital who are on ART at 90 days after hospital discharge

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Collaborators

  • Centre for Infectious Disease Research in Zambia
  • University Teaching Hospital

Registry information

Acronym: COLAH

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
May 18, 2017
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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