HIV and Multi-Drug Resistant Tuberculosis: a Study on Clinical Outcomes

This study aims to investigate the relationship between HIV infection and multi-drug resistant tuberculosis (MDR-TB) among affected individuals in Zahedan, Iran. It will involve a detailed analysis of patient demographics, clinical characteristics, and treatment outcomes to enhance understanding of this co-infection. The findings may inform better treatment strategies and healthcare policies for managing these diseases in similar populations.

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Key information

Conditions

HIV Infection Actinomycetales Infections Bacterial Infections Bacterial Infections and Mycoses Blood-Borne Infections Communicable Diseases Genital Diseases Gram-Positive Bacterial Infections HIV Infections Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections MDR-TB Mycobacterium Infections RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Tuberculosis Tuberculosis, Multidrug-Resistant Urogenital Diseases Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Zahedan University of Medical Sciences

Zahedan, Sistan and Baluchestan, 98167-43463, Iran

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults (aged 18 years and older) diagnosed with both HIV and multi-drug-resistant tuberculosis (MDR-TB).
Studies published in peer-reviewed journals.
Studies that provide data on the co-occurrence of HIV and MDR-TB.
Participants from diverse geographical regions to enhance generalizability.
Studies with clear definitions of MDR-TB according to WHO guidelines.

Exclusion criteria

Studies that focus solely on drug-susceptible tuberculosis without MDR-TB.
Studies involving pediatric populations (under 18 years of age).
Non-original research such as reviews, editorials, and commentaries.
Studies lacking sufficient data on the co-occurrence of HIV and MDR-TB.
Studies that do not adhere to ethical guidelines for human subjects or lack appropriate ethical approvals.

Treatment and study plan

Examination of HIV Infection in Patients with Multi-Drug Resistant Tuberculosis (MDR-TB)

Other

This meta-analysis examines the impact of HIV infection on the prevalence and outcomes of multi-drug resistant tuberculosis (MDR-TB) among affected populations. The analysis synthesizes data from multiple studies conducted across various countries, focusing on the correlation between HIV co-infection and MDR-TB rates, treatment outcomes, and demographic factors. The findings aim to enhance understanding of the complex interactions between HIV and MDR-TB, ultimately informing clinical practices and public health strategies.

Primary outcomes

Prevalence of Multi-Drug Resistant Tuberculosis (MDR-TB) in HIV-Positive Patients

Time frame: Data collected over the course of the studies from 2006 to 2018.

This study aims to determine the prevalence of multi-drug resistant tuberculosis (MDR-TB) among patients co-infected with HIV. Data will be collected from various studies included in the meta-analysis, focusing on the incidence rates of MDR-TB in this population. The analysis will provide insights into the challenges faced in treating HIV-positive individuals with MDR-TB and highlight the need for targeted interventions.

Sponsors and collaborators

Lead sponsor

Zahedan University of Medical Sciences

Other

Registry information

Official study title

HIV Infection Accompanied by Multi-Drug Resistant Tuberculosis: a Decadal Systematic Review and Meta-Analysis

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Nov 4, 2024
Registry last updated: Nov 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed