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Completed

NCT Number: NCT03545841

HIT in People With Type 1 Diabetes

Few people with type 1 diabetes achieve exercise guidelines and many programmes designed to increase physical activity have failed. High-intensity interval training (HIT) has been shown to be a time-efficient alternative to traditional moderate-intensity continuous training (MICT) in various groups without type 1 diabetes. A single bout of HIT does not increase the risk of hypoglycaemia in people with type 1 diabetes. This study aimed to assess whether HIT a safe, effective and time-efficient training strategy to improve cardio-metabolic health and reduce the risk of hypoglycaemia in people with type 1 diabetes.

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Key information

Conditions

Type1diabetes

Study type

Interventional

Phase

Not applicable

Primary location

Liverpool John Moores University

Liverpool, Merseyside, L3 3AF, United Kingdom

About this study

This study aimed to investigate whether 1) six weeks of high-intensity interval training (HIT) induces similar improvements in cardio-metabolic health markers as moderate-intensity continuous training (MICT) in people with type 1 diabetes, and 2) whether HIT abolishes acute reductions in plasma glucose observed following MICT sessions. Fourteen sedentary individuals with type 1 diabetes (n=7 per group) completed six weeks of HIT or MICT 3 times per week. Pre- and post-training measurements were made of 24h interstitial glucose profiles (using continuous glucose monitors (CGMS)) and cardio-metabolic health markers (V ̇O2peak, blood lipid profile and aortic pulse wave velocity; aPWV). Capillary blood glucose concentrations were assessed before and after exercise sessions throughout the training programme to investigate changes in blood glucose during exercise in the fed state.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • duration of type 1 diabetes >6 months
  • basal bolus regimen
  • no significant history of hyper- or hypoglycaemia (determined from medical history)

Exclusion criteria

duration of type 1 diabetes <6 months,

  • insulin pump therapy
  • significant history of hyper- or hypoglycaemia (determined from medical history)
  • obesity (BMI >30 kg∙m-2)
  • pregnancy or planning pregnancy
  • uncontrolled hypertension (>180/100 mmHg)
  • angina, autonomic neuropathy
  • taking any medication that affects heart rate
  • major surgery planned within 6 weeks of the study
  • severe nonproliferative
  • unstable proliferative retinopathy

Treatment and study plan

HIT

Other

Participants completed 6 weeks of HIT

MICT

Other

Participants completed 6 weeks of MICT

Primary outcomes

  1. Maximal aerobic capacity

    Time frame: change in baseline maximal aerobic capacity at 6 weeks

    Maximal aerobic capacity test pre and post 6-week training intervention

Secondary outcomes

  1. Vascular stiffness

    Time frame: change in baseline vascular stiffness at 6 weeks

    Aortic pulse wave velocity to measure vascular stiffness

Sponsors and collaborators

Lead sponsor

Liverpool John Moores University

Other

Registry information

Official study title

High-Intensity Interval Training Improves Aerobic Capacity and Abolishes the Decline in Blood Glucose Observed During Moderate-Intensity Continuous Training Sessions in People With Type 1 Diabetes

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Jun 4, 2018
Registry last updated
Jun 4, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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