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Completed

NCT Number: NCT02733146

Histones and Free-plasma DNA After Cardiac Arrest

To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.

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Key information

Conditions

Heart Arrest Body Temperature Changes Brain Diseases Brain Injuries Cardiovascular Diseases Central Nervous System Diseases Heart Diseases Hypothermia Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Post Cardiac Arrest Syndrome Post-Cardiac Arrest Syndrome Postoperative Complications Reperfusion Injury Signs and Symptoms Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Dept of Anesthesiology and Intensive Care and Dept of Clinical Biochemistry, Aarhus University Hospital

Aarhus, Aarhus N, 8200, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Out of hospital cardiac arrest of presumed cardiac cause
  • Return of spontaneous circulation (ROSC)
  • Glasgow Coma Score < 8
  • Age > 18 years and < 80 years

Exclusion criteria

  • >60 minutes from the circulatory collapse to ROSC
  • Time interval > 4 hours from cardiac arrest to initiation of targeted temperature management
  • Terminal illness
  • Coagulation disorder
  • Unwitnessed asystolia
  • Cerebral performance category 3-4 before the cardiac arrest
  • Severe persistent cardiogenic shock
  • Pregnancy
  • Persistent cardiogenic shock (systolic blood pressure < 80 despite inotropic treatment)
  • New apoplexy or intracerebral hemorrhage
  • Lack of consent from the relatives
  • Lack of consent from the general practitioner
  • Lack of consent from the patient if he/she wakes up and is relevant

Treatment and study plan

cardiac arrest

Other

Primary outcomes

  1. Plasma histones

    Time frame: Approximate 24 hours after cardiac arrest

    The level of plasma histones

  2. Free-plasma DNA

    Time frame: Approximate 24 hours after cardiac arrest

    The level of total free-plasma DNA

Secondary outcomes

  1. Plasma histones

    Time frame: Approximate 48 hours and 72 hours after cardiac arrest

    The level of plasma histones

  2. Free-plasma DNA

    Time frame: Approximate 48 hours and 72 hours after cardiac arrest

    The level of total free plasma DNA

Other outcomes

  1. Simplified Acute Physiology Score (SAPS) score

    Time frame: Approximate 24 hours, 48 hours and 72 hours after cardiac arrest

  2. Platelet count

    Time frame: Approximate 24 hours, 48 hours and 72 hours after cardiac arrest

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

Histones and Free-plasma DNA in the Days Following the Cardiac Arrest

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Apr 11, 2016
Registry last updated
Jun 2, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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